云南松松塔正丁醇提取物对大鼠离体子宫平滑肌的影响  

EFFECTS OF THE N-BUTANOL EXTRACTS FROM THE PINE CONES OF PINUS YUNNANENSIS ON ISOLATED RAT UTERINE SMOOTH MUSCLE

作　　者：马欧 郭美仙 何正春 杨毅雯 MA Ou;GUO Mei-xian;HE Zheng-chun;YANG Yi-wen(Zhaotong Hospital of Traditional Chinese Medicine,Zhaotong,Ynuan 657000,China;College of Pharmacy and Chemistry,Dali University,Dali,Yunan 671000,China)

机构地区：[1]昭通市中医医院,云南昭通657000 [2]大理大学药学与化学学院,云南大理671000

出　　处：《井冈山大学学报（自然科学版）》2019年第5期91-95,共5页Journal of Jinggangshan University (Natural Science)

基　　金：国家自然科学基金项目(81260632);云南省自然科学基金项目(2012FD036)

摘　　要：目的研究云南松松塔正丁醇提取物对大鼠离体子宫平滑肌的作用。方法通过制备大鼠离体子宫标本,观察云南松松塔正丁醇提取物对大鼠离体子宫平滑肌自发收缩活动,催产素及乙酰胆碱诱发收缩活动的影响。结果云南松松塔正丁醇提取物可使正常大鼠自发收缩和催产素及乙酰胆碱诱发收缩的频率减慢、张力减小、活动力减弱。结论云南松松塔正丁醇提取物对大鼠离体子宫平滑肌的收缩活动具有抑制作用,其机制可能跟阻断催产素受体和M受体有关。Objective:To investigate the effects of the n-butanol extracts from the pine cones of Pinus yunnanensis on the isolated rat uterine smooth muscle.Methods:The isolated uterine smooth muscle was prepared from the rats,and then the effects of the n-butanol extracts from the pine cores of P.yunnanensis on spontaneous contractions of isolated rat uterine smooth muscle were evaluated.Moreover,the effects of extracts on the contraction induced by oxytocin and acetylcholine in the isolated rat uterine smooth muscle were evaluated,respectively.Results:The n-butanol extracts from pine core of P.yunnanensis could significantly reduce the spontaneous contraction frequency,tension and uterine activity of the isolated rat uterine smooth muscle.Meanwhile,it also could reduce the contraction frequency,tension and uterine activity of the isolated rat uterine smooth muscle induced by oxytocin and acetylcholin,respectively.Conclusion:The n-butanol extracts from the pine core of P.yunnanensis have an inhibitory effect on the contraction of isolated rat uterine smooth muscle,which may be related to the blocking of oxytocin receptors and M receptors.

关 键 词：云南松松塔 大鼠离体子宫 催产素 乙酰胆碱 

分 类 号：R285.5[医药卫生—中药学]