“浙八味”煎剂治疗非酒精性脂肪性肝炎的前瞻性队列研究  

Prospective Cohort Study of “Eight Zhes” Decoction in the Treatment of Non-alcoholic Steatohepatitis

作　　者：周玉平 杨将领 杨萍[3] 陈珊 郭利华[1] 吕雪幼 ZHOU Yuping;YANG Jiangling;YANG Ping;CHEN Shan;GUO Lihua;LYU Xueyou(The Affiliated Hospital of Medical School of Ningbo University,Ningbo 315020,China;Beilun Hospital of Traditional Chinese Medicine,Ningbo 315800,China;Ningbo College of Health Sciences,Ningbo 315100,China)

机构地区：[1]宁波大学医学院附属医院,浙江宁波315020 [2]宁波市北仑区中医院,浙江宁波315800 [3]宁波卫生职业技术学院,浙江宁波315100

出　　处：《中国现代应用药学》2019年第17期2197-2201,共5页Chinese Journal of Modern Applied Pharmacy

基　　金：浙江省中医药科技计划项目(2019ZB114)

摘　　要：目的探讨中药复方“浙八味”煎剂治疗非酒精性脂肪性肝炎的临床疗效和安全性。方法采用前瞻性队列研究设计,收集非酒精性脂肪性肝炎临床病例,按患者治疗意愿分为试验组和对照组。对照组纳入66例常规西医治疗,予生活方式干预及多烯磷脂酰胆碱胶囊治疗,试验组纳入63例在西医常规治疗基础上给予中药“浙八味”煎剂治疗。疗程均为12周,疗程结束后评估患者中医症候疗效、B超疗效、血肝功能及血脂变化。结果试验组中医症候疗效总有效率显著高于对照组(P<0.01);试验组TG、TC复常率显著高于对照组(P<0.01或P<0.05);2组ALT、AST复常率均为90%左右,无显著性差异;试验组B超总有效率显著高于对照组(P<0.05)。结论非酒精性脂肪性肝炎在西医常规治疗基础上,联合“浙八味”煎剂能显著提高临床疗效。OBJECTIVE To explore the clinical efficacy and safety of“Eight Zhes”decoction in the treatment of non-alcoholic steatohepatitis.METHODS A prospective cohort study design was used.Clinical cases of non-alcoholic steatohepatitis were collected.Patients were divided into experimental group and control group according to their treatment intention.Sixty-six cases in the control group were treated with routine western medicine for lifestyle intervention and treatment with polyene phosphatidy-lcholine capsules.Sixty-three cases in the experimental group were treated with integrated traditional Chinese and western medicine,received“Eight Zhes”decoction treatment.The course of treatment was 12 weeks,evaluate the curative effect of TCM symptoms,B-ultrasound,blood-liver function and blood lipid changes in patients.RESULTS The total effective rate of TCM symptoms in the experimental group was significantly higher than that in the control group(P<0.01).The normalization rate of TG and TC in the experimental group was significantly higher than that in the control group(P<0.01 or P<0.05).The normalization rates of ALT and AST in both groups were about 90%,there was no significant difference between the two groups.Besides,according to the results of B-ultrasound,the total effective rate of the experimental group was significantly higher than that of the control group(P<0.05).CONCLUSION The results suggest that,the traditional Chinese medicine“Eight Zhes”decoction can significantly improve the clinical efficacy in the treatment of non-alcoholic steatohepatitis on the bases of routine western medicine.

关 键 词：非酒精性脂肪性肝炎 浙江道地药材 “浙八味”煎剂 队列研究 

分 类 号：R285.6[医药卫生—中药学]