苦碟子治疗中枢神经系统疾病机制研究进展  

Advances in the Mechanism of Kudiezi in the Treatment of Central Nervous System Diseases

作　　者：韩先楚 邹敬韬 李璐 张海峰 卢丽辉 侯圣群 王芳 HAN Xianchu;ZOU Jingtao;LI Lu;ZHANG Haifeng;LU Lihui;HOU Shengqun;WANG Fang(Life Science and Biopharmaceutics School,Shenyang Pharmaceutical University,Shenyang 110016,China;Faculty of Functional Food and Wine,Shenyang Pharmaceutical University,Shenyang 110016,China;Tonghua Huaxia Pharmaceutical Co.,Ltd.,Tonghua 134100,China;Engineering Research Center for Research and Development of Plant Polyphenols of Liaoning Province,Shenyang 110016,China)

机构地区：[1]沈阳药科大学生命科学与生物制药学院,沈阳110016 [2]沈阳药科大学功能食品与葡萄酒学院,沈阳110016 [3]通化华夏药业有限责任公司,吉林通化134100 [4]辽宁省植物多酚研究与开发技术工程中心,沈阳110016

出　　处：《中国现代应用药学》2019年第17期2222-2227,共6页Chinese Journal of Modern Applied Pharmacy

基　　金：辽宁省教育厅项目(2016101633L3);沈阳药科大学中青年教师事业发展支持计划(ZQN2016002)

摘　　要：苦碟子为菊科苦荬菜属植物抱茎苦荬菜[Ixeris sonchifolia(Bge.)Hance]干燥全草。苦碟子在我国资源丰富,药理作用广泛,除对心血管疾病具有良好的治疗作用外,其在脑血管疾病等中枢神经系统疾病的治疗上也越来越受到人们的关注。本文综述了苦碟子治疗脑缺血等中枢神经系统疾病机制方面的研究新进展,包括清除自由基、抑制钙超载、炎症相关因子和相关通路、调节相关蛋白表达等,从而推动其在中枢神经系统疾病治疗方面的深入开发和应用。Kudiezi is the dry whole grass of Ixeris sonchifolia(Bge.)Hance with rich resources in China and a wide range of pharmacological effects.It not only has a good therapeutic effect on cardiovascular diseases,but also attracts more and more attention in the treatment of central nervous system diseases such as cerebrovascular diseases.This review summarizes the new mechanism progress of Kudiezi in the treatment of central nervous system diseases,including clearance of free radicals,inhibition of calcium overload,inflammation-related factors and related pathways,regulatory proteins,etc,so as to promote its further development and application in the treatment of central nervous system diseases.

关 键 词：苦碟子 抱茎苦荬菜 中枢神经系统疾病 机制 

分 类 号：R285.5[医药卫生—中药学]