计算机辅助训练对轻度认知功能障碍的干预性研究  

Efficacy of computer-assisted cognitive training in mild cognitive impairment

作　　者：王丽娟 刘欣 王红霞 刘荧 吕娜 李皓 Wang Lijuan;Liu Xin;Wang Hongxia(Department of Neurology,Zhongguancun Hospital of Beijing,Beijing 100190,China)

机构地区：[1]中关村医院神经内科

出　　处：《中国康复》2019年第9期473-476,共4页Chinese Journal of Rehabilitation

基　　金：北京市中关村医院科研培育专项(201704)

摘　　要：目的:探究计算机辅助训练对轻度认知功能障碍(MCI)的干预性研究。方法:连续收集年龄≥60岁的轻度认知功能障碍(MCI)患者100例,随机分为治疗组与对照组各50例,对照组给予健康宣教与危险因素控制,治疗组在对照组的基础上联合计算机辅助认知训练,每周3次,每次30min,共6个月。在治疗前、治疗后3、6、12个月,采用蒙特利尔认知评估量表(MoCA)和工具性日常生活能力(IADL)量表进行评价。结果:在治疗3、6、12个月后,治疗组MoCA值均明显高于干预前及同时间对照组(P<0.01),在治疗6个月、12个月时对照组MoCA值较干预前明显升高(P<0.01),2组之间存在交互作用(F=158.6,P<0.01)。治疗12个月后,2组IADL评分均明显高于治疗前(P<0.01),且治疗组的IADL明显高于对照组(P<0.01)。结论:对MCI患者进行早期筛查、健康宣教、危险因素控制及计算机辅助认知功能训练的综合干预,可有效改善认知功能障碍,减缓认知功能障碍发展,提高生活质量。Objective:To investigate the intervention of computer-assisted cognitive training in mild cognitive impairment(MCI).Methods:One-hundred MCI patients aged 60 years old or over were randomly divided into two group:observation group(50 cases),accepting computer-assisted cognitive training,health education and risk factors control;control group(50 cases),only accepting health education and risk factors control.The computer-assisted cognitive training was given 30 min every time,3 times every week for 6 months.The cognitive and psychosocial assessments were performed by MoCA and IADL scales at baseline(M0),and 3 months(M3),6 months(M6),and 12 months(M12)post-intervention.Results:The average MoCA scores in the observation group were significantly higher after treatment for 3,6 and 12 months than those before intervention and control group correspondingly(P<0.01).At M6 and M12,the MoCA scores in the control group were significantly higher than those before intervention(P<0.01).A crossover effect occurred between the two groups in multiple repeated measures(F=158.6,P<0.01).At M12,the IADL scores in both groups were significantly higher than before intervention(P<0.01),and those in the observation group were significantly higher than in control group(P<0.01).Conclusion:The comprehensive cognitive intervention can effectively improve cognitive deficit,reduce cognitive decline and improve the quality of life.

关 键 词：认知训练 轻度认知功能障碍 干预 

分 类 号：R49[医药卫生—康复医学] R749.16[医药卫生—临床医学]