Graphdiyne oxide enhances the stability of solid contact-based ionselective electrodes for excellent in vivo analysis  

作　　者：Lijun Zhao Ying Jiang Jie Hao Huan Wei Wei Zheng Lanqun Mao 

机构地区：[1]Beijing National Laboratory for Molecular Sciences,Key Laboratory of Analytical Chemistry for Living Biosystems,Institute of Chemistry,the Chinese Academy of Sciences,Beijing 100190,China [2]Institute of Surface/Interface Science and Technology,Key Laboratory of Superlight Material and Surface Technology of Ministry of Education,College of Materials Science and Chemical Engineering,Harbin Engineering University,Harbin 150001,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Science China Chemistry》2019年第10期1414-1420,共7页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China (21790390, 21790391, 21621062, 21435007) for Lanqun Mao;the National Basic Research Program of China (2016YFA0200104);the Chinese Academy of Sciences (QYZDJ-SSW-SLH030)

摘　　要：Quantitively and stably tracking ion dynamics in the living brain of animals is essential to understanding many physiological and pathological processes.Solid-state ion-selective electrodes(ISEs)are powerful tools for monitoring the dynamic change of ions at physiological concentration range;however,the unintentional accumulation of an aqueous layer at the ion selective membrane/solid contact interface compromises the electrode potential stability,limiting its in vivo application.Here,using manganese dioxide(MnO2)and potassium ISE(K-+ISE)as model solid contact and ISEs,we demonstrate for the first time that graphdiyne oxide(GDYO)can enhance the potential stability of solid contact-based ISEs.Our results suggest that the intrinsic structural and hydrophobic features of GDYO,plays a key role in impeding and stabilizing the formation of water layer.With GDYO-MnO2 acting as the solid contact,the K-+ISE displays an excellent short-term potential stability and maintains great selectivity,achieving reliable K+sensing at the animal level.The GDYO-based strategy is generalizable to different ISEs and does not require complicated processing steps,paving an exciting opportunity for in vivo ion recognition and sensing.Quantitively and stably tracking ion dynamics in the living brain of animals is essential to understanding many physiological and pathological processes. Solid-state ion-selective electrodes（ISEs） are powerful tools for monitoring the dynamic change of ions at physiological concentration range; however, the unintentional accumulation of an aqueous layer at the ion selective membrane/solid contact interface compromises the electrode potential stability, limiting its in vivo application. Here, using manganese dioxide（MnO2） and potassium ISE（K-+ISE） as model solid contact and ISEs, we demonstrate for the first time that graphdiyne oxide（GDYO） can enhance the potential stability of solid contact-based ISEs. Our results suggest that the intrinsic structural and hydrophobic features of GDYO, plays a key role in impeding and stabilizing the formation of water layer. With GDYO-MnO2 acting as the solid contact, the K-+ISE displays an excellent short-term potential stability and maintains great selectivity,achieving reliable K+ sensing at the animal level. The GDYO-based strategy is generalizable to different ISEs and does not require complicated processing steps, paving an exciting opportunity for in vivo ion recognition and sensing.

关 键 词：in VIVO analysis graphdiyne OXIDE solid-state ION selective electrodes water layer 

分 类 号：O64[理学—物理化学]