射血分数正常心力衰竭中医证候分布特点的文献分析  

Literature analysis on characteristics of traditional Chinese medicine syndromes of heart failure with normal ejection fraction

作　　者：赵志强[1] 李达 王贤良[1] 毕颖斐[1] 王群有 成涛 汤岐梅 毛静远[1] ZHAO Zhi-qiang;LI Da;WANG Xian-liang;BI Ying-fei;WANG Qun-you;CHENG Tao;TANG Qi-mei;MAO Jing-yuan(The First Teaching Hospital,Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;Graduates School,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)

机构地区：[1]天津中医药大学第一附属医院,天津300381 [2]天津中医药大学研究生院,天津300193

出　　处：《中华中医药杂志》2019年第9期4047-4050,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金青年科学基金项目(No.81202852);教育部“创新团队发展计划”(No.IRT_16R54);国家中医药管理局国家中医临床研究基地业务建设科研专项(No.JDZX2015005);天津市科技计划项目(No.16ZXMJSY00050,No.15ZXLCSY00020);天津市优秀青年教师资助计划~~

摘　　要：目的:基于文献分析总结射血分数正常心力衰竭(HFNEF)中医证候要素分布及组合规律。方法:检索中国期刊全文数据库(CNKI)、万方数据库(WANFANG)、中文科技期刊全文数据库(VIP)、中国生物医学文献数据库(CBM)建库至2017年5月发表的HFNEF中医证候相关文献,提取证候要素,对其进行统计分析。结果:共纳入文献15篇,病例2 202例。主要合并疾病依次为高血压病(61.71%)、冠心病(38.93%)、糖尿病(15.74%)、高脂血症(13.38%)。HFNEF中医证候要素特征如下:所占比例>10%证候要素依次为气虚(58.04%)>血瘀(48.41%)>阴虚(27.66%)>阳虚(26.16%)>痰浊(22.66%)>水饮(18.71%)。根据文献来源划分南北地区,不同证候要素在南北地区文献中的分布存在一定差别。气虚、阴虚、水饮在南方地区文献中相对多见,气滞、湿邪、火(热)邪在北方地区相对多见。结论:HFNEF中医证候要素为本虚标实,虚性证候要素依次为气虚>阴虚>阳虚,实性证候要素依次为血瘀>痰浊>水饮;不同证候要素在南北地区文献中的分布存在差异。Objective: To analyze and summarize the distribution and combination characteristics of traditional Chinese medicine(TCM) syndromes of heart failure with normal ejection fraction(HFNEF) based on literature. Methods: TCM syndromes on HFNEF searched from China National Knowledge Internet(CNKI), WanFang Data, VIP Data, China biological medical(CBM) literature database until May, 2017 were extracted and analyzed. Results: A total of 2 202 cases of TCM syndromes with HFNEF were analyzed and extracted from total 15 enrolled articles. The comorbidities were hypertension(61.71%), coronary heart disease(38.93%), diabetes(15.74%), and hyperlipidemia(13.38%). TCM syndrome elements with proportion larger than 10%were qi deficiency(58.04%), blood stasis(48.41%), yin deficiency(27.66%), yang deficiency(26.16%), turbid phlegm(22.66%), fluid retention syndrome(18.71%) successively. TCM syndrome elements were different between northern and southern regions. The frequency of deficiency, yin deficiency and fluid retention syndrome are higher in the southern region, while that of qi stagnation, dampness pathogen and fire(heat) pathogen could be observed more in the northern Parts. Conclusion: Qi deficiency, blood stasis, yin deficiency, yang deficiency, turbid phlegm and fluid retention syndrome are the main TCM syndrome elements in HFNEF Patients. Different distributions of TCM syndrome elements could be observed between southern and northern regions.

关 键 词：射血分数正常心力衰竭 中医证候要素 分布规律 文献分析 

分 类 号：R25[医药卫生—中医内科学]