揿针治疗青光眼小梁切除术后干眼症的随机对照临床研究  

Randomized controlled trial of dry eye syndrome after trabeculectomy treated with pyonex

作　　者：刘红佶 张秀清 汪伟 李翔[4] 李祥玉 李华宏 LIU Hong-ji;ZHANG Xiu-qing;WANG Wei;LI Xiang;LI Xiang-yu;LI Hua-hong'(Academy of Ophthalmology,Chengdu University of TCM,Chengdu 610075,China;Department of Ophthalmology,MEM Ophthalmologic Hospital,Beijing 100036,China;Department of Ophthalmology,Kunming Municipal Hospital of Traditional Chinese Medicine,Kunming 650041,China;Department of Ophthalmology,The Teaching Hospital of Chengdu University of TCM,Chengdu 610075,China)

机构地区：[1]成都中医药大学眼科学院,成都610075 [2]北京美尔目眼科医院眼科,北京100036 [3]云南省昆明市中医院眼科,昆明650041 [4]成都中医药大学附属医院眼科,成都610075

出　　处：《中华中医药杂志》2019年第9期4437-4440,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：四川省科技厅项目(No.18YYJC);四川省中医药管理局项目(No.2018LC008);成都中医药大学科技发展基金项目(No.ZRYY1706)~~

摘　　要：目的:观察揿针治疗青光眼小梁切除术后干眼症的临床疗效,评价其有效性。方法:采用单中心完全随机、阳性药对照、平行组设计,将120例(120眼)青光眼小梁切除术后干眼症患者随机分为观察组1(揿针)、观察组2(揿针与0.1%玻璃酸钠滴眼液)和对照组(0.1%玻璃酸钠滴眼液),疗程3周。观察3组治疗前后的泪膜破裂时间(BUT)、泪液分泌试验(SIt)、角膜荧光素钠染色(FL)及干眼相关眼部症状。结果:观察组2总有效率90.0%显著优于观察组1的67.5%及对照组72.5%(P<0.01);且观察组2 BUT、SIt、FL评分较观察组1及对照组显著改善(P<0.01);观察组2干涩感较观察组1及对照明显减轻(P<0.01,P<0.05),观察组2及观察组1的烧灼感、刺痛感、眼痒感较对照组有所减轻(P<0.05)。结论:揿针能明显改善青光眼小梁切除术后干眼症状(尤其是干涩感、烧灼感、刺痛感、眼痒感);联合0.1%玻璃酸钠滴眼液疗效更佳,值得临床推广应用。Objective: To observe the clinical curative effect of pyonex for dry eye syndrome after trabeculectomy of glaucoma, and evaluate its effectiveness. Methods: A completely random of one center, positive drug control, parallel group clinical trial was designed. This study included one hundred and twenty cases(120 eyes) of patients with dry eye syndrome after trabeculectomy, which were randomly divided into three groups: observation group 1(treated with pyonex), observation group 2(treated with pyonex and 0.1% sodium hyaluronate eye drop), and the control group(treated with 0.1% sodium hyaluronate eye drop). All groups were treated for 3 weeks. Then the break-up time(BUT), Schirmer test(SIt), corneal sodium fluorescein staining(FL) and ocular symptoms about dry eye syndrome were observed before and after the treatment. Results: The total treatment effective rate of observation group 2(90.0%) was significant higher than that of observation group 1(67.5%) and the control group(72.5%)(P<0.01). The BUT, SIt and FL score of observation group 2 were significant better than that of observation group 1 and the control group(P<0.01). In addition, dryness sensation in observation group 2 was alleviated than observation group 1 and the control group(P<0.01, P<0.05). Burning, tingling and itching sensation in observation group 2 and observation group 1 were reliever than the control group(P<0.05). Conclusion: Pyonex can obviously alleviate symptoms of dry eye(especially burning, tingling and itching sensation) after trabeculectomy of glaucoma;the curative effect will be better combination with 0.1% sodium hyaluronate eye drop and is worth to be promotion and application in the clinical.

关 键 词：干眼症 揿针 青光眼小梁切除术 玻璃酸钠滴眼液 临床观察 

分 类 号：R47[医药卫生—护理学]