萘替芬酮康唑乳膏治疗皮肤真菌病安全性与有效性的meta分析  

Meta-analysis of the efficacy and safety of naftifine hydrochloride and ketoconazole cream for the dermatomycoses

作　　者：付洁 吴斌[1] FU Jie;WU Bin(Department of pharmacy,South Campus,Ren Ji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 201112,China)

机构地区：[1]上海交通大学医学院附属仁济医院南院药剂科

出　　处：《中国真菌学杂志》2019年第5期270-276,共7页Chinese Journal of Mycology

基　　金：第四轮公共卫生三年行动计划重点学科—循证公共卫生与卫生经济学基金(15GWZK0901)

摘　　要：目的综合评价萘替芬酮康唑乳膏治疗皮肤真菌病的有效性及安全性。方法在The Cochrane Library、Medline、Embase、CBM、中国知网(CNKI)、维普和万方数据库上检索萘替芬酮康唑乳膏与其他抗真菌药物单药治疗皮肤真菌病的随机对照研究,用NoteExpress进行文献筛选及资料提取,使用RevMan5.3进行系统评价。结果最终纳入43篇文献,共5413名患者,治疗有效率为85.27%。分析结果显示萘替芬酮康唑乳膏疗效优于硝酸咪康唑[RR=1.32,95%CI(1.26,1.38)],优于联苯苄唑治疗4周组[RR=1.31,95%CI(1.12,1.54)],优于酮康唑[RR=1.25,95%CI(1.14,1.36)]。萘替芬酮康唑在复发率及不良反应发生率上低于其他药物。结论萘替芬酮康唑乳膏可有效治疗皮肤真菌病,且更加安全。Objective To evaluate the efficacy and safety of naftifine hydrochloride and ketoconazole cream for the dermatomycoses.Methods Searching for database about randomized controlled trials(RCT)of naftifine hydrochloride and ketoconazole cream and other antifungal drug monotherapy to treat the dermatomycoses in Cochrane Library,Medline,Embase,CBM,CNKI,VIP database,Wanfang database.Literature screening and data extraction was conducted in software NoteExpress.Meta-analysis was performed with RevMan5.3.Results Finally,43 RCTs were included with a total of 5413 patients.The analysis showed that the effective rate of naftifine hydrochloride and ketoconazole cream was 85.27%.The analysis showed that the efficacy of naftifine hydrochloride and ketoconazole cream was better than that of miconazole nitrate[RR=1.32,95%CI(1.26,1.38)],bifonazole treatment for 4-week group[RR=1.31,95%CI(1.12,1.54)],and ketoconazole[RR=1.25,95%CI(1.14,1.36)].Compared with other drugs,naftifine hydrochloride and ketoconazole cream had lower relapse rate and incidence of adverse reactions.Conclusions Naftifine hydrochloride and ketoconazole cream is effective and safe in the treatment of dermatomycoses.

关 键 词：萘替芬酮康唑 皮肤真菌病 有效性 安全性 

分 类 号：R756[医药卫生—皮肤病学与性病学]