热毒净联合阿昔洛韦对小儿传染性单核细胞增多症的临床疗效  

Clinical effect on children’s infectious mononucleosis treated with redujing and acyclovir

作　　者：陈双雯 刘萍萍 业晓青 谢宝强 张小兰 CHEN Shuang-wen;LIU Ping-ping;YE Xiao-qing;XIE Bao-qiang;ZHANG Xiao-lan(Jiangning Hospital Affiliated to Nanjing Medical University,Nanjing Jiangsu 211100)

机构地区：[1]南京医科大学附属江宁医院

出　　处：《世界中西医结合杂志》2019年第9期1267-1270,共4页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的观察热毒净联合阿昔洛韦治疗小儿传染性单核细胞增多症的临床疗效和安全性以及对T淋巴细胞亚群的影响。方法选取2015年2月至2017年5月期间就诊的86例小儿传染性单核细胞增多症患儿,按临床治疗方法不同分为治疗组45例和对照组41例。对照组给予常规的对症及支持治疗以及阿昔洛韦注射液10 mg/(kg·d),混入150 ml的5%葡萄糖注射液中,静脉滴注,2次/d,治疗组在对照组的基础上给予口服热毒净口服液治疗,年龄≤3岁者5 ml/次,3次/d;年龄>3岁者10 ml/次,3次/d。两组患儿疗程均为14 d。观察记录两组患儿的临床疗效,各种临床症状的改善时间,治疗后两组患儿白细胞、EB病毒抗体、异常淋巴结细胞水平恢复的时间以及不良反应发生的情况,比较治疗前后两组患儿T淋巴细胞亚群的情况。结果治疗后治疗组患儿总有效率为95.6%,对照组总有效率为75.6%,治疗组总有效率显著高于对照组,差异具有统计学意义(P<0.05)。治疗后治疗组患儿体温恢复正常的时间、淋巴结缩小时间、咽峡炎缓解时间、肝脾恢复正常时间均优于对照组,差异有统计学意义(P<0.05)。治疗后治疗组患儿WBC、EB病毒抗体、异常淋巴结细胞水平恢复时间明显优于对照组,差异具有统计学意义(P<0.05)。两组患儿治疗后CD3+、CD8+水平均显著低于治疗前,CD4+、CD4+/CD8+水平显著高于治疗前,差异具有统计学意义(P<0.05);治疗后治疗组CD3+、CD8+水平显著低于对照组,CD4+、CD4+/CD8+水平明显高于对照组,差异具有统计学意义(P<0.05)。结论热毒净联合阿昔洛韦治疗小儿传染性单核细胞增多症能显著改善患儿的临床症状,提高临床疗效,调节T淋巴细胞亚群的水平。Objective To observe the clinical effect and safety on children′s infectious mononucleosis treated with redujing and acyclovir as well as the impacts on T-lymphocyte subset.Methods From February 2015 through to May 2017,86 cases of children′s infectious mononucleosis were collected and divided into a treatment group(45 cases)and a control group(41 cases)according to clinical therapeutic methods.In the control group,the patients were treated with the routine symptomatic and supporting therapy as well as the intravenous drip with acyclovir injection 10 mg/(kg·d),mixed with glucose injection,5%,150 ml,twice a day.In the treatment group,on the base of the treatment as the control group,redujing oral liquid was prescribed for oral administration,5 ml each time,three times a day for the children≤3 years old,or 10 ml each time,three times a day for the children>3 years old.The duration of treatment was 14 days in the two groups.The clinical effect,the improvement time of each clinical symptom,the recovery time of WBC,EB viral antibody and abnormal lymph node cells as well as the adverse reactions were observed after treatment in the two groups.T-lymphocyte subset was compared before and after treatment in the two groups.Results The total effective rate was 95.6%in the treatment group and was 75.6%in the control group after treatment and the total effective rate in the treatment group was higher significantly than the control group,indicating the statistical difference(P<0.05).After treatment,the recovery time of normal body temperature,the time of lymph node shrinking,the remission time of isthmitis and the recovery time of the liver and spleen in the treatment group were all superior to the control,indicating the statistical significance(P<0.05).After treatment,the recovery time of WBC,EB viral antibody and lymph node cells in the treatment group were all better obviously than the control group,indicating the statistical significance(P<0.05).After treatment,the levels of CD3+and CD8+were lower significantly than

关 键 词：热毒净 阿昔洛韦 小儿传染性单核细胞增多症 临床疗效 T淋巴细胞亚群 

分 类 号：R725.5[医药卫生—儿科]