柴芩双术汤联合胰酶肠溶胶囊对慢性胰腺炎患者血清sICAM-1、sVCAM-1水平的影响  

Effects on serum sICAM-1 and sVCAM-1 in the patients with chronic pancreatitis treated with chaiqin shuangzhu decoction and pancreatin enteric-coated capsules

作　　者：路毅 张勤生[2] LU Yi;ZHANG Qin-sheng(Gushi County People′s Hospital,Xinyang Henan 465200;Henan Chinese Medicine Hospital,Zhengzhou Henan 450000)

机构地区：[1]固始县人民医院,河南信阳465200 [2]河南省中医院,河南郑州450000

出　　处：《世界中西医结合杂志》2019年第9期1319-1323,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：河南省科技厅科技攻关项目(112102310693)

摘　　要：目的观察柴芩双术汤联合胰酶肠溶胶囊对慢性胰腺炎(CP)患者血清可溶性细胞间粘附分子-1(sICAM-1)、可溶性血管细胞粘附分子-1(sVCAM-1)水平的影响。方法选取2016年3月—2017年3月期间收治的CP患者116例作为研究对象,按照随机数字表法分为治疗组和对照组各58例,两组均给予基础干预,对照组给予胰酶肠溶胶囊治疗,治疗组在对照组基础上联合柴芩双术汤治疗,持续治疗4周。观察两组治疗前后中医证候积分、粪便特征指标、血清淀粉酶、脂肪酶、对氧磷酶-1活性及sICAM-1、sVCAM-1水平,比较两组临床疗效。结果治疗后两组中医证候积分较治疗前显著降低(P<0.05),且治疗组显著低于对照组(P<0.05);治疗后两组粪便脂肪含量、粪便含氮量、大便质量、大便频率较治疗前显著降低(P<0.05),且治疗组显著低于对照组(P<0.05);治疗后两组血清淀粉酶和脂肪酶活性较治疗前显著降低、对氧磷酶-1活性较治疗前显著升高(P<0.05),且治疗组显著优于对照组(P<0.05);治疗后两组血清sICAM-1、sVCAM-1水平较治疗前显著降低(P<0.05),且治疗组显著低于对照组(P<0.05);治疗组总有效率为94.83%,显著高于对照组72.41%(P<0.05)。结论柴芩双术汤联合胰酶肠溶胶囊治疗CP疗效肯定,可改善患者血清sICAM-1、sVCAM-1水平。Objective To observe the effects on serum sICAM-1 and sVCAM-1 in the patients with chronic pancreatitis treated with chaiqin shuangzhu decoction and pancreatin enteric-coated capsules.Methods A total of 116 patients with chronic pancreatitis were collected from March 2016 through to March 2017.According to the random number table,they were divided into a treatment group and a control group,58 cases.The basic intervention was given in the two groups.Additionally,pancreatin enteric-coated capsules were given in the control group.On the base of the control group,chaiqin shuangzhu decoction was combined.The treatment lasted 4 weeks in the two groups.Before and after treatment,TCM symptom scores,faces characteristics indexes,serum amylase,lipase and paraoxonase-1 activity and sICAM-1 and sVCAM were observed in the two groups.The clinical effects were compared between the two groups.Results TCM symptom score were reduced significantly after treatment as compared with that before treatment in the two groups(P<0.05).The result in the treatment group was lower significantly than the control group(P<0.05).After treatment,the content of fat and nitrogen in faces,the quality of faces and the frequency of defecation were reduced significantly as compared with those before treatment and the results in the treatment group were lower significantly than the control group(P<0.05).After treatment,serum amuylase and lipase activity was reduced significantly as compared with that before treatment in the two groups,the paraoxonase-1 activity was increased significantly(P<0.05)and the results in the treatment group were better than the control group(P<0.05).After treatment,the levels of serum sICAM-1 and sVCAM-1 were reduced significantly as compared with those before treatment in the two groups and the results in the treatment group were lower significantly than the control group(P<0.05).The total effective rate was 94.83%in the treatment group,higher significantly than 72.41%in the control group(P<0.05).Conclusion The combined treatm

关 键 词：柴芩双术汤 胰酶肠溶胶囊 慢性胰腺炎 可溶性细胞间粘附分子-1 可溶性血管细胞粘附分子-1 

分 类 号：R657.5[医药卫生—外科学]