颅脑损伤患者使用血凝酶的止血效果  

Hemocoastatic Effects of Hemagterase for Cranial Brain Injury Patients

作　　者：王洋[1] 龙贻文[2] WANG Yang;LONG Y-iwen(Shanghai Eighth People’s Hospital Emergency Department Shanghai 200235,China;Shanghai Jiaotong University Medical College affiliated ruijin Hospital Luwan Branch Of Intensive Medical Department,Shanghai,200020)

机构地区：[1]上海市第八人民医院急诊科,上海200235 [2]上海市交通大学医学院附属瑞金医院卢湾分院重症医学科,上海200020

出　　处：《血栓与止血学》2019年第5期735-737,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的探讨使用血凝酶对颅脑损伤患者的止血效果。方法选择2016年1月至2019年6月期间本院神经外科住院部收治的颅脑损伤患者120例,采用随机数字表法将患者分为血凝酶组和止血敏组,各60例。又观察其止血效果与对凝血功能(Fbg,aPTT,PT,TT)与血小板聚集率(PAR)的影响。结果血凝酶组平均出血量明显少于止血敏组,治疗前,两组Hb、HCT水平比较差异无统计学意义(P>0.05),治疗后,两组Hb,HCT水平较治疗前明显降低,P<0.05;止血敏组Hb,HCT水平下降更为明显(P<0.05)。治疗前,两组Fbg、aPTT、PT、TT与PAR水平比较差异无统计学意义(P>0.05),治疗后,两组PAR水平较治疗前明显上调,(P<0.05);两组治疗前后、aPTT、PT水平比较差异无统计学意义(P>0.05)。治疗后,血凝酶组Fbg,TT水平较止血敏但明显降低(P<0.05);显示血凝酶组的类凝血酶作用。结论血凝酶对颅脑损伤患者止血效果满意,且不增加血栓性疾病的发生风险。Objective To explore the hemostatic effects of Hemagterase for Cranial Brain Injury Patients.Methods 120 patients with craniofacial brain injury were admitted to the hospital’s neurosurgery hospital department between January 2016 and June 2019,and patients were divided into hemagterase group and dicynone group by random numerical table.The effect of hemorrhage and effects on clotting function(Fbg,aPTT,PT,TT)and platelet aggregation(PAR)was also observed.Results The average bleeding volume of hemagterase group was significantly less than that of the dicynone group,and before treatment,the two groups had no statistical difference in Hb and HCT levels(P<0.05),and after treatment,hb,HCT levels were significantly lower than before treatment,(P<0.05)。Prior to treatment,the difference between Hb and HCT levels was not statistically significant(P<0.05),after treatment,Hb,HCT levels were significantly lower than before treatment,(P<0.05),and after treatment,The PAR levels in both groups were significantly higher than before treatment The difference between aPTT and PT levels before and after treatment in the two groups was not statistically significant(P<0.05),.After treatment,the hemagterase group Fbg,TT level was lower than dicynone group(P<0.05).Conclusion Hemagterase was satisfied with the hemostatic effect of patients with cranial brain injury and did not increase the risk of thrombosis.

关 键 词：颅脑损伤 血凝酶 止血敏 

分 类 号：R651.15[医药卫生—外科学]