瘢痕妊娠阴式加固术后电刺激治疗修复子宫内膜有效性研究  

Study on the effectiveness of endometrial repair after bio-electrical stimulation for patients with cesarean scar pregnancy after vaginal reinforcement

作　　者：李环[1] 罗晓君 张巍颖[1] 胡艳[1] 王苏梅[1] 杜辉[1] 梁金涛 吴瑞芳[1] LI-Huan;LUO Xiao-jun;ZHANG Wei-ying;HU Yan;WANG Su-mei;DU-Hui;LIANG Jin-tao;WU Rui-fang(Department of Obstetrics and Gynecology,Peking University Shenzhen Hospital,Shenzhen Key Laboratory on Technology for Early Diagnosis of Major Gynecological Diseases,Shenzhen Technical Research and Development Center on Gynecologic Diseases,Shenzhen518035,China)

机构地区：[1]北京大学深圳医院深圳市女性重大疾病诊断实验室,深圳市妇科肿瘤医学工程技术研究开发中心

出　　处：《妇产与遗传（电子版）》2019年第2期40-45,共6页Obstetrics-Gynecology and Genetics (Electronic Edition)

摘　　要：目的通过对剖宫产瘢痕妊娠患者阴式加固术后进行仿生物电刺激治疗,探讨仿生物电刺激治疗在瘢痕妊娠阴式加固术后的患者中促进盆底血液循环,加速子宫内膜修复,改善子宫内膜容受性的应用价值,希望能找到一种有效安全,无创简便的改善子宫内膜功能的新方法。方法对2016年1月至2018年2月在北京大学深圳医院因瘢痕妊娠行清宫及阴式加固术患者共82例,随机分为干预组42例及对照组40例,干预组进行1Hz,270μs及40 Hz,20μs的序贯电刺激治疗,监测治疗前后的月经量改变、子宫内膜形态分型差异、子宫动脉血流灌注情况差异、子宫内膜厚度差异,同期对照组监测以上指标。结果干预组与对照组在年龄、孕次、距上次剖宫产时间、停经时间之间的差异无统计学意义(P>0.05);干预组、对照组治疗前在月经量、子宫内膜形态、子宫内膜动脉血流分型、子宫动脉血流灌注、子宫内膜厚度等指标中差异无统计学意义(P>0.05),治疗后差异有统计学意义(P<0.05)。结论仿生物电刺激治疗对于改善剖宫产瘢痕妊娠术后患者的子宫内膜形态、子宫内膜血流情况、子宫内膜厚度、宫内膜修复有明显效果。Objective By applying bio-electrical stimulation to patients with cesarean scar pregnancy(CSP)after vaginal reinforcement,the application value of bioelectrical stimulation in promoting pelvic floor blood circulation,accelerating endometrial repair and improving endometrial receptivity for patients after CSP surgery is explored,hoping to find a new way to improve fertility that is effective,safe,non-invasive and simple.Methods A total of 82 patients who underwent curettage and vaginal reinforcement because of CSP in Peking University Shenzhen Hospital from January 2016 to February 2018 is randomly divided into treatment group(n=42)and control group(n=40).Patients in the treatment group were treated with sequential electrical stimulation at 1 Hz,270μs and 40 Hz,20μs.Changes in menstrual volume before and after treatment,differences in endometrial morphology,uterine arterial blood perfusion and endometrial thickness were observed.In the same period,monitor all those differences and changes that mentioned above in the control group.Results The difference between the intervention group and the control group in age,gestation times,time from last cesarean section and time of menopause has no statistics significance(P>0.05).There was no significant difference in menstrual volume,endometrial morphology,endometrial artery blood flow pattern,uterine artery blood perfusion and endometrial thickness before treatment between the intervention group and the control group(P>0.05)and there were significant differences after treatment(P<0.05).Conclusions Bio-electric stimulation has significant therapeutic effects on improving endometrial morphology,endometrial blood flow,endometrial thickness,promoting endometrial repair.

关 键 词：仿生物电刺激 剖宫产瘢痕妊娠 子宫内膜 生育力 

分 类 号：R714.2[医药卫生—妇产科学]