湖北钟祥长寿老人代谢综合征与血清总胆红素的相关性分析  

Relationship between metabolic syndrome and total bilirubin in nonagenarians and centenarians living in Hubei Zhongxiang Province

作　　者：章桂芬 王桦[1] 叶光明[2] 董昱 檀春玲 Zhang Guifen;Wang Hua;Ye Guangming;Dong Yu;Tan Chunling(Department of Geriatric,Zhongnan Hospital,Wuhan University,Wuhan 430071,China;Department of Clinical Laboratory,Zhongnan Hospital,Wuhan University,Wuhan 430071,China)

机构地区：[1]武汉大学中南医院老年病科,430071 [2]武汉大学中南医院检验科,430071

出　　处：《中华内分泌代谢杂志》2019年第9期752-755,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：湖北省老龄办资助项目(HBLLB2017004)。

摘　　要：代谢综合征与心、脑、肾脏等靶器官损伤密切相关。胆红素是一种有效的抗氧化剂,目前尚缺乏长寿老年人群代谢综合征和血清总胆红素的研究数据。本研究调查湖北省钟祥市长寿老人的代谢综合征患病率及其与总胆红素的相关性。根据钟祥民政局提供的人口学信息,走访调研,纳入≥90岁长寿老人共128名,剔除不符合标准者11名,有效对象共计117名。对其进行问卷调查、体格检查和血液标本采集。117名长寿老人年龄90~113岁,平均年龄(98.6±4.8)岁,其中男性30名,女性87名。肥胖者占19.7%,高血糖者占29.9%,高血压者占94.0%,高三酰甘油者占33.3%,低HDL-C血症者占17.1%;代谢综合征患病率为23.9%。经logistic回归分析,总胆红素水平与代谢综合征、高三酰甘油呈负相关(P<0.05),与肥胖、高血糖、高血压、总胆固醇无相关性(P>0.05)。湖北钟祥长寿人群中代谢综合征患病率较低,总胆红素水平与代谢综合征、高三酰甘油呈负相关。Metabolic syndrome is closely related to target organ injury such as heart, brain, and kidney. And bilirubin is an effective antioxidant. At present, there is a lack of research data on metabolic syndrome and serum total bilirubin in longevity elderly people. This study aimed to study the prevalence of the metabolic syndrome and its correlation with serum total bilirubin level in nonagenarians and centenarians living in Hubei Zhongxiang Province. According to the demographic information provided by Zhongxiang Civil Affairs Bureau, 128 elderly people were interviewed and 11 of them were excluded. A total of 117 population were included in the study. Questionnaires, physical examination, and blood test were made. 117 subjects aged 90-113 years with an average age of (98.6±4.8) years old were analysed. The prevalence of metabolic syndrome and its diagnostic components were obesity 19.7%, hyperglycemia 29.9%, hypertension 94.0%, hypertriglyceridemia 33.3%, low high density lipoprotein-cholesterol (HDL-C) levels 17.1%, and metabolic syndrome 23.9%. Logistic regression analysis found that the total bilirubin level was negatively correlated with metabolic syndrome and triglyceride levels(P<0.05), but not with obesity, hyperglycemia, hypertension, and total cholesterol (P>0.05). The nonagenarians and centenarians have a low prevalence of metabolic syndrome in Zhongxiang, Hubei Province, total bilirubin was negatively correlated with metabolic syndrome and triglyceride.

关 键 词：长寿老人 代谢综合征 总胆红素 

分 类 号：R54[医药卫生—心血管疾病]