大剂量激素冲击治疗对视力威胁型Graves眼病的治疗效果  

Therapeutic outcomes of high-dose intravenous steroids in the treatment of sight-threatening Graves′ ophthalmopathy

作　　者：黄明诗 单忠艳[1] 李玉姝[1] Huang Mingshi;Shan Zhongyan;Li Yushu(Department of Endocrinology and Metablolism,China Medical University Affiliated the First Hospital,Insitude of Endocrinnology,Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院内分泌科,内分泌研究所,沈阳110001

出　　处：《中华内分泌代谢杂志》2019年第9期784-788,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(81770784)。

摘　　要：Graves眼病是一种以眼眶周围炎症和眼眶周围软组织的浸润性病变为特征的自身免疫性疾病。约3%~7%的Graves眼病患者由于眼睑闭合不全致角膜溃疡和(或)视神经受压,继而进展为视力威胁型Graves眼病。患者视力急剧下降、辨色力下降,严重影响患者的生活质量。本文通过对比2例使用大剂量激素冲击治疗前后的效果,并结合国内外研究进展探讨视力威胁型Graves眼病激素冲击治疗的最适方案。Graves′ ophthalmopathy is a complex autoimmune disease characterized by inflammation and the orbital connective/adipose tissue with infiltration. About 3% to 7% of patients with Graves′ ophthalmopathy can have severe or very severe course of disease. In severe forms of Graves′ ophthalmopathy, there might occur considerable exophthalmos complicated in some cases with corneal ulceration due to incomplete closure of the eyelids and (or) pressure on optic nerve leading to neuropathy (dysthyroid optic neuropathy). The patient′s visual acuity and the color perception decreased sharply , which seriously affected the patients quality of life. In this paper, we explore effective therapies by compared the effects of high-dose intravenous steroids for the treatment of sight-threatening Graves′ ophthalmopathy in 2 cases.

关 键 词：GRAVES眼病 视力威胁型Graves眼病 甲状腺相关眼病性视神经病变 

分 类 号：R58[医药卫生—内分泌]