支架孔率对模拟乙状窦憩室内血流动力学的影响  

Impact of stent porosity on hemodynamics in simulated sigmoid sinus diverticulum

作　　者：杨开兰 金龙[1] 乔爱科[2] 王斯睿 韩燕京 杨泽冉 YANG Kailan;JIN Long;QIAO Aike;WANG Sirui;HAN Yanjing;YANG Zeran(Department of Interventional Radiology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;College of Life Science and Bio-engineering,Beijing University of Technology,Beijing 100124,China)

机构地区：[1]首都医科大学附属北京友谊医院放射介入科,北京100050 [2]北京工业大学生命科学与生物工程学院,北京100124

出　　处：《中国介入影像与治疗学》2019年第10期630-634,共5页Chinese Journal of Interventional Imaging and Therapy

基　　金：首都医科大学附属北京友谊医院科研启动基金(yyqdkt2016-21)

摘　　要：目的探讨支架孔率对模拟乙状窦憩室内血流动力学的影响。方法基于计算流体力学(CFD)方法构建理想化乙状窦憩室血流动力学模型(S0模型,无支架),观察支架孔率75%、50%、25%模型(分别对应S1、S2、S3模型)的血流动力学变化。结果S0、S1、S2、S3模型乙状窦憩室内血流速度分别为12.65、4.68、2.20及0.41 mm/s。相对于S0模型,S1、S2、S3模型血流速度分别降低了63.00%(7.97/12.65)、82.61%(10.45/12.65)和96.76%(12.24/12.65)。乙状窦憩室远侧壁的高压力区及高壁面切应力(WSS)区随支架孔率降低而逐渐减小,整个憩室内压力及WSS分布趋于均匀。S0、S1、S2、S3模型乙状窦憩室内压力分别为64.04、63.86、62.54及60.95 Pa,各模型压力值差异不明显。结论低孔率支架可明显改善模拟乙状窦憩室内血液流动和血流动力学应力条件。Objective To investigate the impact of stent porosity on hemodynamics in the simulated sigmoid sinus diverticulum.Methods An idealized hemodynamic model of sigmoid sinus diverticulum(S0 model,no stent)was constructed based on computational fluid dynamics(CFD).The hemodynamic changes in models stented with different porosities of 75%,50%and 25%(corresponding to S1,S2,S3 model)were observed.Results The mean flow velocities in sigmoid sinus diverticulum of model S0,S1,S2 and S3 was 12.65,4.68,2.20 and 0.41 mm/s,respectively.Compared with model S0,the velocities in model S1,S2 and S3 decreased by 63.00%(7.97/12.65),82.61%(10.45/12.65)and 96.76%(12.24/12.65),respectively.The area of high pressure and high wall shear stress(WSS)in diverticulum distal wall reduced gradually with the decrease of stent porosity.Meanwhile,the pressure and WSS tended to distribute uniformly in the entire diverticulum.However,the mean pressures for model S0,S1,S2 and S3 in diverticulum(64.04,63.86,62.54 and 60.95 Pa,respectively)showed no significant change.Conclusion Stent with lower porosity can significantly improve blood flow and hemodynamic stress conditions in the simulated sigmoid sinus diverticulum.

关 键 词：耳鸣 颅窦 憩室 血流动力学 介入治疗 支架 

分 类 号：R764.45[医药卫生—耳鼻咽喉科] R815[医药卫生—临床医学]