原发性肾病综合征患儿治疗前后血脂变化及相关因素分析  

Serum Lipid Profile in Children with Primary Nephrotic Syndrome before and after Treatment and Correlation Analysis

作　　者：曹禺[1] 黄燕萍[1] 吴红艳[1] 刘丽 余辉[2] CAO Yu;HUANG Yanping;WU Hongyan;LIU Li;YU Hui(Department of Pediatrics,the First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,China;Department of Pediatric surgery,the Second Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710004,China)

机构地区：[1]西安交通大学第一附属医院儿科,西安710061 [2]西安交通大学第二附属医院儿外科,西安710004

出　　处：《宁夏医科大学学报》2019年第7期678-680,689,共4页Journal of Ningxia Medical University

基　　金：陕西省青年科技新星(2019KJXX-048)

摘　　要：目的观察原发性肾病综合征(PNS)患儿治疗前后血脂的变化特点,并探讨其相关因素。方法收集在我院初诊为PNS患儿共51例(PNS组),男性39例,女性12例,平均年龄(6.9±0.9)岁;健康对照组儿童48例(对照组),男性35例,女性13例,平均年龄(7.4±0.3)岁,观察两组儿童随访期间饮食状况、PNS患儿治疗前、后血脂各指标、血清白蛋白的水平及其相关因素。结果PNS组患儿在随访期间饮食控制率与对照组儿童差异无统计学意义(P>0.05);与对照组比较,PNS组患儿血清总胆固醇(TC)、甘油三酯(TG)、载脂蛋白B(ApoB)、载脂蛋白E(ApoE)、低密度脂蛋白(LDL)升高(P均<0.05),血清白蛋白(ALB)降低(P<0.05);PNS患儿血清TC、ApoB、ApoE、LDL较治疗前降低(P均<0.05),ALB较治疗前升高(P<0.05);而TG、载体蛋白A(ApoA)、高密度脂蛋白(HDL)治疗前后差异无统计学意义(P>0.05)。PNS组患儿TG与ApoE呈正相关(r=0.81,P=0.00)。结论PNS患儿经规范治疗后血清TG水平变化不大,相关分析提示与ApoE水平呈正相关。Objective To evaluate the changes of serum lipids in children with primary nephrotic syndrome(PNS)before and after treatment and to explore the factors which affected serum triglycerides(TG).Methods Total 51 PNS children(39 males and 12 females,with an average age of[(6.9±0.9)years]and 48 healthy controls(35 males and 13 females,with an average age of[(7.4±0.3)years]were collected in our hospital.Diets of subjects from two groups during follow-up period were recorded,serum lipid and albumin were tested in PNS group before and after treatment,and related factors were analyzed.Results There was no significant difference in the diet control rate between NS group and healthy control group during follow-up(P>0.05).Serum TC,TG,ApoB,ApoE and LDL significantly increased(P<0.05),but serum albumin significantly decreased compared with normal control group(P<0.05).Serum TC,ApoB,ApoE and LDL significantly decreased(P<0.05),ALB significantly increased(P<0.05),while TG,ApoA and HDL had no significant change(P>0.05)after treatment in PNS group.There was a positive correlation between TG and ApoE in PNS group(P<0.05).Conclusion The serum TG level of PNS children did not change significantly after standard treatment,and the correlation analysis indicated that there was a positive correlation between the serum TG level and ApoE level.

关 键 词：肾病综合征 儿童 甘油三酯 载脂蛋白E 

分 类 号：R692[医药卫生—泌尿科学]