黄芪、丹参配伍提取物在心肌梗死中的促血管新生作用  

ANGIOGENESIS PROMOTING EFFECT OF COMPATIBLE EXTRACTS OF ASTRAGALUS MEMBRANACEUS AND SALVIA MILTIORRHIZA IN MYOCARDIAL INFARCTION

作　　者：张瓅方 李梦华[2] 毛秉豫 ZHANG Li-fang;LI Meng-hua;MAO Bing-yu(Henan Key Laboratory of Zhang Zhongjing Formulae and Herbs for Immuoregulation,Zhang Zhongjing School of Chinese Medicine,Nanyang Institute of Technology,Nanyang 473004,China;Nanyang Medical College,Nanyang 473061,China)

机构地区：[1]南阳理工学院张仲景国医国药学院河南省张仲景方药与免疫调节重点实验室,河南南阳473004 [2]南阳医学高等专科学校,河南南阳473061

出　　处：《南阳理工学院学报》2019年第4期106-110,共5页Journal of Nanyang Institute of Technology

基　　金：国家自然科学基金项目(81173372,81473438);河南省高等学校重点科研项目(19A360031);南阳市科技攻关项目(KJGG2018077)

摘　　要：目的:观察黄芪、丹参配伍提取物在心肌梗死中的促血管新生作用。方法:依据中医“益气化瘀生新”理论和西医“治疗性促血管新生”概念,选用黄芪、丹参配伍提取物进行心肌梗死的干预治疗。分别采用动物模型、离体细胞培养等多种实验方法,运用分子生物、药物化学等现代研究技术,明确黄芪、丹参配伍提取物的促血管新生机制。结果:黄芪、丹参配伍提取物在心肌梗死中可通过多靶点、多通路调控,有效发挥促血管新生作用。结论:以中药黄芪、丹参为代表的益气化瘀类药物在缺血性疾病中发挥着重要的防治作用,为中医药治疗此类疾病提供丰富的诊疗思路和参考依据。Objective:Angiogenesis promoting effect of compatible extracts of Astragalus membranaceus and Salvia miltiorrhiza in myocardial infarction.Methods:According to the theory of"Yiqi Yushengxin"in TCM and the concept of"therapeutic angiogenesis promoting"in Western medicine,The compatible extracts of Astragalus membranaceus and Salvia miltiorrhiza were selected for the intervention treatment of myocardial infarction.Animal models,in vitro cell culture and other experimental methods were used,and modern research techniques such as molecular biology and pharmacochemistry were used.To clarify the mechanism of promoting angiogenesis of compatible extracts of Astragalus membranaceus and Salvia miltiorrhiza.Result:The compatible extracts of Astragalus membranaceus and Salvia miltiorrhiza can effectively promote angiogenesis th The drugs of Invigorating Qi and stasis,represented by Astragalus membranaceus and Salvia miltiorrhiza,play an important role in the prevention and treatment of ischemic diseases.rough multi-target and multi-channel regulation in myocardial infarction.Conclusion:To provide rich diagnostic and therapeutic ideas and reference basis for the treatment of this kind of disease with traditional Chinese medicine.

关 键 词：黄芪 丹参 心肌梗死 血管新生 

分 类 号：R285[医药卫生—中药学]