一氧化碳中毒迟发性脑病发病机制的研究  

The Study of Pathogenesis of Delayed Encephalopathy After Acute Carbon Monoxide Poisoning

作　　者：刘鹏[1] 田文生[1] LIU Peng;TIAN Wen-Sheng(The Hohhot First Hospital,Hohhot 010059 China)

机构地区：[1]呼和浩特市第一医院

出　　处：《内蒙古医学杂志》2019年第9期1043-1046,共4页Inner Mongolia Medical Journal

摘　　要：生活和生产环境中广泛存在着最常见的窒息性气体-一氧化碳(carbon monoxide,CO),部分急性CO中毒患者在经过约20~60 d的“假愈期”,还会出现急性一氧化碳中毒迟发脑病(Delayed Encephalopathy After Acute Carbon Monoxide Poisoning,DEACMP),该病致残率高,目前尚无有效治疗措施。多位学者针对DEACMP开展了大量的基础和临床研究。在查阅大量近期相关文献后,关于其发病机制归纳出以下几种学说:缺血缺氧学说、血管因素学说、血流变异常学说、细胞凋亡学说、细胞自噬学说、免疫反应学说、自由基学说、兴奋性氨基酸学说。我们对迄今为止该病发病机制的主要研究成果做一综述,以期为临床诊疗提供新的思路和依据。The most common asphyxiating gas,carbon monoxide(CO),exists widely in living and production environments.After regaining their consciousness and going through latent phase days to several weeks(about 20~60 d),part patients with CO poisoning will occur delayed encephalopathy after acute carbon monoxide poisoning(DEACMP).The disability rate of the disease is high and there is no effective treatment.A large number of basic and clinical studies have been carried out on carbon monoxide toxic encephalopathy by many savants.After the end of consulting many relevant documentation,we can induce following main theroies of pathogenesis:theroy of Hypoxia ischenia、theroies of Hemorheology、theroy of abnormality apoptosis、theroy of autophagy、theroy of immune response、theroy of free radical、theroy of excitaory amino acid.We wish for providing new train and basis for clinic diagnosis and treatment of DEACMP by colligating correletated document and writing the review.

关 键 词：急性一氧化碳中毒 一氧化碳中毒迟发性脑病 

分 类 号：R595[医药卫生—内科学]