Sestrins在调控衰老中的作用  

Role of Sestrins in Regulating Aging

作　　者：陈波[1] 李志杰[1] CHEN Bo;LI Zhijie(Medical Research Center,Shengjing Hospital,China Medical University,Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院医学研究中心辽宁省环境与代谢疾病动物模型研究与应用重点实验室

出　　处：《中国医科大学学报》2019年第10期931-935,共5页Journal of China Medical University

基　　金：国家自然科学基金(81472359)

摘　　要：活性氧(ROS)的过度累积和哺乳动物雷帕霉素复合物1机械靶点(mTORC1)的慢性激活是衰老和年龄相关性退行性病变的典型促发因素。Sestrins是一类高度保守的应激诱导蛋白,是ROS和mTORC1信号通路的重要负调控因子。近年来,关于Sestrins信号及其分子性质的研究已有突破性发现,揭示了衰老和年龄相关退行性病变新的潜在的治疗方向。本文就Sestrins在调控衰老中的作用研究进展进行综述。Excess accumulation of reactive oxygen species(ROS)and chronic activation of mechanistic target of rapamycin complex 1(mTORC1)are typical triggers for aging and age-related degeneration.Sestrins are a family of highly conserved stress-induced proteins.They are important negative regulators of ROS and mTORC1 signaling pathways.Recent research has clarified the signaling and molecular properties of Sestrins,and revealed potential therapeutic directions for aging and age-related degenerative diseases.This paper reviews the research progress of Sestrins in regulating aging.

关 键 词：Sestrins 调控 衰老 

分 类 号：R339.3[医药卫生—人体生理学]