体素内非相干运动磁共振弥散加权成像定量参数在肝癌中的应用价值  

The application value of quantitative parameters of IVIM-DWI in hepatocellular carcinoma

作　　者：吴笋 蒋小莉 王娟艳 WU Sun;JIANGXiao-li;WANG Juan-yan(Department of Radiology,Jingmen NO.2 People's Hospital,Jingmen 448000,China)

机构地区：[1]荆门市第二人民医院放射科

出　　处：《中国医学装备》2019年第10期55-58,共4页China Medical Equipment

摘　　要：目的:探讨体素内非相干运动(IVIM)磁共振弥散加权成像(DWI)定量参数在肝癌中的应用价值。方法:选取120例肝癌患者将其纳入研究组,其中病理分级Ⅰ级58例,Ⅱ级36例,Ⅲ级26例;另选同期120名健康体检者纳入对照组。两组均行磁共振常规序列、DWI及IVIM序列扫描,测量并比较两组定量参数表观弥散系数(ADC)、灌注分数(f)、真实弥散系数(D)及灌注相关弥散系数(D^*)值,并通过绘制受试者工作特征(ROC)曲线分析各参数值对肝癌的诊断效能。结果:研究组患者的ADC和D值低于对照组,其差异有统计学意义(t=3.650,t=4.518;P<0.05);研究组患者的f和D^*值高于对照组,其差异有统计学意义(t=2.395,t=5.612;P<0.05);病理分级Ⅰ级患者的ADC和D值高于Ⅱ级,Ⅱ级高于Ⅲ级,Ⅰ级患者的f和D^*值低于Ⅱ级,Ⅱ级低于Ⅲ级,不同病理分级患者定量参数ADC、f、D及D^*值比较差异均有统计学意义(F=3.547,F=1.032,F=4.012;P<0.05);ROC曲线显示:ADC、f、D及D^*值诊断肝癌的曲线下面积分别为0.799、0.600、0.700和0.593,其中ADC和D值的诊断效能优于f和D*值,其对应的最佳诊断阈值分别为2.011×10^-3mm^2/s和2.141×10^-3mm^2/s。结论:IVIM-DWI检查对肝癌微循环功能评估具有较高的应用价值,其定量参数有助于肝癌的病理分级诊断,且ADC和D值具有较高的诊断效能。Objective:To investigate the application value of quantitative parameters of intravoxel incoherent motion-diffusion weighted imaging(IVIM-DWI)in hepatocellular carcinoma(HCC).Methods:120 patients with HCC were enrolled in the study group,of which 58 cases were grade I,and 36 cases were grade II and 26 cases were grade III as pathological grading.Another 120 healthy examinees in the same period were selected as the control group.Both groups underwent the scans of routine MR sequence,DWI and IVIM sequence.Apparent diffusion coefficient(ADC),perfusion fraction(f),true diffusion coefficient(D)and perfusion-related diffusion coefficient(D^*)between the two groups were measured and compared.The diagnostic efficiency of each parameter for HCC was analyzed by drawing receiver operating characteristic(ROC)curve.Results:The ADC value and D value of study group were significantly lower than those of control group(t=3.650,t=4.518,P<0.05).The values of f and D^* of patients in study group were significantly higher than those in control group(t=2.395,t=5.612,P<0.05).The ADC value and D value of patients with pathological grade I were significantly higher than those of patients with grade II,and those of patients with grade II were significantly higher than those of patients with grade III,and the f value and D^*value of patients with grade I were significantly lower than those of patients with grade II,and those of patients with grade II were significantly lower than those of patients with grade III,and there were significant differences in ADC value,f value,D value and D^*value among patients with different pathological grades(F=3.547,F=1.032,F=4.012,P<0.05).ROC curve showed:the areas under curve(AUC)of ADC value,f value,D value and D^*value in diagnosing HCC were 0.799,0.600,0.700 and 0.593,respectively.Among them,the diagnostic efficiency of ADC value and D value were better than those of F and D^*values,and the corresponding optimally diagnostic thresholds was 2.011×10^-3mm/s and 2.141×10^-3mm/s,respectively.Conclusion:T

关 键 词：肝癌 体素内非相干运动 弥散加权磁共振成像 定量参数 微循环功能 

分 类 号：R445.2[医药卫生—影像医学与核医学]