吸入激素联合噻托溴铵治疗哮喘-慢阻肺重叠综合症的临床效果  

Clinical effect of inhaled corticosteroid combined with Tiotropium Bromide in the treatment of asthma-chronic obstructive pulmonary disease overlap syndrome

作　　者：许硕[1] XU Shuo(Department of Respiratory Medicine,Ganzhou People’s Hospital,Jiangxi Province,Ganzhou341000,China)

机构地区：[1]江西省赣州市人民医院呼吸内科

出　　处：《中国当代医药》2019年第27期70-72,共3页China Modern Medicine

摘　　要：目的探究吸入激素联合噻托溴铵治疗哮喘-慢阻肺重叠综合症的临床效果。方法选取2017年6月~2018年6月我院收治的60例哮喘-慢阻肺重叠综合症患者作为研究对象,采用随机数字表法分为对照组与观察组,每组各30例。对照组患者采用单一吸入激素的方式进行治疗,观察组在单一激素吸入治疗的基础上增加噻托溴铵治疗。比较两组患者的肺功能情况、哮喘症状(ACT)评分、慢性阻塞性肺疾病症状(CAT)评分情况以及用药后并发症的发生情况。结果两组患者治疗前的最大肺活量(FEV1)、残总比(RV/TLC)以及吸气分数(IC/TLC)、ACT及CAT评分比较,差异均无统计学意义(P>0.05)。治疗后,观察组患者的IC/TLC与FEV1高于对照组,而RV/TLC低于对照组,差异均有统计学意义(P<0.05)。治疗后,观察组患者心悸、口干舌燥、排尿不畅、口腔念珠菌感染的总发生率低于对照组,ACT评分高于对照组,CAT评分低于对照组,差异均有统计学意义(P<0.05)。结论吸入激素联合噻托溴铵在哮喘-慢性阻肺重叠综合症患者治疗中的应用与单一吸入激素治疗相比效果更佳,且能够降低并发症的发生率,促进患者肺功能的恢复,降低患者哮喘及慢阻肺症状的发生,具有较高的临床应用价值,值得进行广泛的推广和应用。Objective To investigate the therapeutic effect of inhaled corticosteroid combined with Tiotropium Bromide in the treatment of patients with asthma-chronic obstructive pulmonary disease(COPD)overlap syndrome.Methods Sixty patients with asthma-COPD overlap syndrome who were admitted to our hospital from June 2017 to June 2018 were selected as the subjects.They were divided into the control group and the observation group by random number table method,with 30 cases in each group.In the control group,corticosteroid inhalation alone was used,while in the observation group,Tiotropium Bromide was added on the basis of corticosteroid inhalation.The pulmonary function,asthma control test(ACT)score,COPD assessment test(CAT)score,and the occurrence of complications after medication were compared between the two groups.Results There were no significant differences in the forced expiratory volume in one second(FEV1),residual volume/total lung capacity(RV/TLC),and inspiratory capacity/total lung capacity(IC/TLC),ACT score or CAT score between the two groups before the treatment(P>0.05).After treatment,the ratio of IC/TLC and FEV1 in the observation group were higher than those in the control group,and RV/TLC was lower compared with that in the control group,with statistical significance(P<0.05).The total incidence of palpitations,dry mouth,inhibited urination,and oral candida infection was lower than that of the control group after treatment(P<0.05).The ACT score of the observation group was higher than that of the control group,and CAT score was lower than that of the control group after treatment,and the differences were statistically significant(P<0.05).Conclusion The application of inhaled corticosteroid combined with Tiotropium Bromide in the treatment of patients with asthma-COPD overlap syndrome is better than inhaled corticosteroid therapy alone,and can reduce the incidence of complications and promote the recovery of lung function,and reduce the occurrence of asthma and COPD patients,which has high clinical value and

关 键 词：哮喘-慢阻肺重叠综合症 吸入激素治疗 噻托溴铵 

分 类 号：R562.25[医药卫生—呼吸系统]