沙美特罗替卡松干粉剂治疗支气管哮喘的效果  

Effect of Salmeterol Fluticasone Propionate in the treatment of bronchial asthma

作　　者：宋庆军[1] 杜林 申廷栋 肖涛 SONG Qing-jun;DU Lin;SHEN Ting-dong;XIAO Tao(Department of Respiration,Changqing District People′s Hospital of Ji′nan City,Shandong Province,Ji′nan,250300,China)

机构地区：[1]济南市长清区人民医院呼吸科

出　　处：《中国当代医药》2019年第27期109-112,共4页China Modern Medicine

摘　　要：目的探讨沙美特罗替卡松干粉剂治疗支气管哮喘的效果。方法选取2017年3月~2018年11月我院收治的103例支气管哮喘患者作为研究对象,按照随机数字表法将其分为对照组(51例)与观察组(52例)。对照组患者联合使用羟萘酸沙美特罗吸入粉雾剂和丙酸氟替卡松吸入气雾剂治疗,观察组患者采用沙美特罗替卡松干粉剂治疗。比较两组的治疗效果、治疗前后肺功能[第1秒用力呼气容积(FEV1)、FEV1占用力吸气肺活量(FVC)的比例(FEV1/FVC)、最大呼气流量(PEF)]情况及晨间最大呼气峰值流速(PEFam)。结果两组患者治疗前的FEV1、FEV1/FVC及PEF比较,差异无统计学意义(P>0.05);两组患者治疗后的FEV1、FEV1/FVC及PEF均高于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后的FEV1、FEV1/FVC及PEF均高于对照组,差异有统计学意义(P<0.05)。两组患者治疗前的PEFam比较,差异无统计学意义(P>0.05);两组患者治疗后第1、2、3、4周的PEFam均显著高于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后第1、2、3、4周的PEFam均显著高于对照组,差异有统计学意义(P<0.05)。观察组患者的治疗总有效率为94.23%,明显高于对照组的84.31%,差异有统计学意义(P<0.05)。结论使用沙美特罗替卡松干粉剂治疗支气管哮喘可以有效地改善患者的肺功能,增加呼气流速,缓解其临床症状,治疗效果更明显。Objective To explore the effect of Salmeterol Fluticasone Propionate in the treatment of bronchial asthma.Methods A total of 103 patients with bronchial asthma admitted to our hospital from March 2017 to November 2018 were selected as the study objects,and they were divided into control group(51 cases)and observation group(52 cases)according to the random number table method.The control group was treated with Salmeterol Hydroxynaphthoate Powder for Inhalation combined with Fluticasone Propionate Inhaled Aerosol,and the observation group was treated with Salmeterol Fluticasone Propionate.The therapeutic effect,pulmonary function(forced expiratory volume in the first second[FEV1),ratio of FEV1 occupational forced vital capacity[FVC][FEV1/FVC],peak expiratory flow[PEF])and maximum peak expiratory flow rate in the morning(PEFam)before and after treatment were compared in the two groups.Results There were no significant differences in FEV1,FEV1/FVC and PEF between the two groups before treatment(P>0.05).The FEV1,FEV1/FVC and PEF of the two groups after treatment were higher than those before treatment,and the differences were statistically significant(P<0.05).The FEV1,FEV1/FVC and PEF of the observation group after treatment were higher than those of the control group,and the differences were statistically significant(P<0.05).There was no significant difference in PEFam between the two groups before treatment(P>0.05).The PEFam at the first,second,third,and fourth weeks after treatment in both groups were significantly higher than those before treatment,and the differences were statistically significant(P<0.05).The PEFam at the first,second,third,and fourth weeks after treatment in the observation group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of the treatment in the observation group was 94.23%,which was significantly higher than that in the control group(84.31%),and the difference was statistically significant(P<0.05)

关 键 词：支气管哮喘 羟萘酸沙美特罗吸入粉雾剂 丙酸氟替卡松吸入气雾剂 沙美特罗替卡松干粉剂 肺功能 

分 类 号：R562.25[医药卫生—呼吸系统]