子痫前期患者血清STOX1、sFlt-1与病情及妊娠结局的关系  

Relationship between serum STOX1, sFlt-1 and state of illness and pregnancy outcome in patients with preeclampsia

作　　者：刘筠[1] 李萍[1] 张敏[1] Yun Liu;Ping Li;Min Zhang(Department of Obstetrics,Tianjin Hospital of ITCWM Nankai Hospital,Tianjin 300100,China)

机构地区：[1]天津市南开医院产科

出　　处：《中国现代医学杂志》2019年第20期96-100,共5页China Journal of Modern Medicine

摘　　要：目的探讨子痫前期(PE)患者血清STOX1、可溶性Fms样酪氨酸激酶-1(sFlt-1)与病情及妊娠结局的关系。方法选取2017年6月-2018年6月于天津市南开医院接受治疗的PE患者92例,其中50例轻度PE患者作为轻度PE组、42例重度PE患者作为重度PE组,另选取同期在该医院进行产检的健康妊娠女性50例作为对照组。比较3组研究对象的平均动脉压、24 h尿蛋白定量、血清STOX1、sFlt-1水平及妊娠结局,分析PE患者血清STOX1、sFlt-1水平与平均动脉压、24 h尿蛋白定量的相关性,分析PE患者不良妊娠结局的影响因素。结果重度PE组和轻度PE组平均动脉压、24 h尿蛋白定量及血清STOX1和sFlt-1水平高于对照组(P<0.05),重度PE组高于轻度PE组(P<0.05);重度PE组胎儿死亡、羊水污染≥Ⅲ度、胎儿宫内窘迫、HELLP综合征、胎盘早剥、子痫、心衰及肺水肿发生率均高于对照组和轻度PE组(P<0.05);轻、重度PE组的血清STOX1、sFlt-1水平与平均动脉压、24 h尿蛋白定量均呈正相关(P<0.05);不同平均动脉压、24 h尿蛋白定量、STOX1及sFlt-1的不良妊娠结局发生率比较,差异有统计学意义(P<0.05)。结论PE患者血清STOX1、sFlt-1水平与病情及妊娠结局密切相关。Objective To investigate the relationship between serum STOX1,soluble Fms-like tyrosine kinase-1(sFlt-1)and state of illness and pregnancy outcome in patients with preeclampsia(PE).Methods Totally 92 patients with PE who were treated in our hospital from June 2017 to June 2018 were enrolled.Among them,50 patients with mild PE were included in the mild PE group and 42 patients with severe PE were included in the severe PE group.Another 50 healthy pregnant women who underwent maternity examination in the hospital during the same period were selected as healthy control group.The mean arterial pressure,24 h urine protein quantitation and serum STOX1,sFlt-1 levels and pregnancy outcome were compared in the three groups.The correlation between serum STOX1 and sFlt-1 levels and mean arterial pressure and 24 h urine protein quantitation were analyzed.The influencing factors of adverse pregnancy outcomes in patients with PE were analyzed.Results After t-test,the mean arterial pressure,24 h urine protein quantitation and serum STOX1,sFlt-1 levels in the severe PE group and the mild PE group were higher than those in the healthy control group(P<0.05),and those in the severe PE group were higher than those in mild PE group(P<0.05),and the difference was statistically significant(P<0.05).After x2-test,the incidence of amniotic fluid pollution≥III degree,intrauterine distress and HELLP syndrome in the severe PE group was higher than that in healthy control group and mild PE group,and the difference was statistically significant(P<0.05).Pearson analysis showed that serum STOX1 and sFlt-1 levels were positively correlated with mean arterial pressure and 24 h urine protein quantitation in the mild PE group and the severe PE group(P<0.05).Univariate analysis showed that there were significant differences in mean arterial pressure,24 h urinary protein quantification,STOX1 and sFlt-1 by x2-test(P<0.05).Conclusions The levels of serum STOX1 and sFlt-1 in patients with PE are closely related to the state of illness and pregnancy out

关 键 词：子痫 血蛋白质类 妊娠结局 

分 类 号：R714.2[医药卫生—妇产科学]