有氧运动用于动脉粥样硬化大鼠对VEGF、ET-1及C/F值影响的实验研究  

Experimental study on the effect of aerobic exercise on vascular growth factor,ET-1 and C/F value in atherosclerotic rats

作　　者：施巍[1] 王丙聚 宋辉 SHI Wei;WANG Bing-ju;SONG Hui(Department of Cardiology,Shangluo Central Hospital,Shangluo Shaanxi 726000,China;Department of Neurology,Xianyang Hospital,Yan'an University,Yan'an Shaanxi 712000,China;Electrocardiogram Room,Ankang Central Hospital,Ankang Shaanxi 725000,China)

机构地区：[1]商洛市中心医院心电科,陕西商洛726000 [2]延安大学咸阳医院神经内科,陕西咸阳712000 [3]陕西省安康市中心医院心电图室,陕西安康725000

出　　处：《临床和实验医学杂志》2019年第19期2045-2049,共5页Journal of Clinical and Experimental Medicine

基　　金：陕西省教育厅科学研究基金项目(编号:16JK1867)

摘　　要：目的研究有氧运动对动脉粥样硬化大鼠模型血清血管内皮生长因子(VEGF)、内皮素(ET-1)、毛细血管与肌纤维数比值(C/F)的影响。方法选取Wistar雄性健康大鼠28只,以随机数表法分为A、B、C、D四组,每组7只,A组给予标准饲料喂养,B、C、D三组经维生素D3灌胃后给予高脂饲料进行喂养,持续喂养20周,自喂养之日起C、D组大鼠每日行60 min、120 min有氧运动,并持续至喂养结束。实验结束后比较四组大鼠左室舒张末期内径(LVDD)、左室收缩末期内径(LVSD)、左室后壁厚度(LVP-WT)、室间隔厚度(IVST)、左心室射血分数(LVEF)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、VEGF、ET-1、C/F各项指标差异。结果四组大鼠LVEF水平比较:B组<C组<D组<A组,差异有统计学意义(P<0.05);四组大鼠LVEDD、LVEDS、LVP-WT、IVST水平比较:B组>C组>D组>A组,差异有统计学意义(P<0.05)。四组大鼠TC、TG、HDL-C、LDL-C水平比较B组>C组>D组>A组,差异有统计学意义(P<0.05)。四组大鼠VEGF、ET-1比较B组>C组>D组>A组,差异有统计学意义(P<0.05);四组大鼠C/F比较:B组<C组<D组<A组,差异有统计学意义(P<0.05)。结论有氧运动能够改善动脉粥样硬化大鼠心功能,降低血脂,下调VEGF、ET-1,提高C/F,且随着运动时间的延长各项指标改善效果越显著。Objective To study the effects of aerobic exercise on serum VEGF,et-1 and the ratio of capillaries to muscle fibers in atherosclerosis rat model.Methods 28 healthy Wistar male rats were selected and divided into four groups(A,B,C and D)by random number table method,with 7 rats in each group.Standard feed was given to group A,and high-fat feed was given to group B,C and D after intragastric administration of vitamin D3 for 20 weeks.From the day of feeding,the rats in group C and D did aerobic exercise for 60 and 120 minutes every day,and the exercise lasted until the end of feeding.After the experiment,the left ventricular LVEDD,LVEDS,lvp-wt,IVST,LVEF,TC,TG,hdl-c,ldl-c,VEGF,et-1 and C/F of the four groups of rats were compared.Results The levels of LVEF in four groups were significantly different(P<0.05),group B<group C<group D<group A.The levels of LVEDD,LVEDS,LVP-WT and IVST in four groups were significantly different,group B>group C>group D>group A(P<0.05).The levels of TC,TG,HDL-C and LDL-C in four groups were significantly different,group B>group C>group D>group A(P<0.05).The levels of VEGF and ET-1 among the four groups were significant different,group B>group C>group D>group A(P<0.05).There was significant difference in C/F,group B<group C<group D<group A(P<0.05).Conclusion Aerobic exercise can improve the cardiac function of atherosclerosis rats,reduce blood lipid,down-regulate VEGF and et-1,and improve C/F,and the improvement effect of various indicators becomes more significant with the extension of exercise time.

关 键 词：大鼠 动脉粥样硬化 有氧运动 血管内皮成长因子 内皮素 毛细血管与肌纤维数比值 

分 类 号：R54[医药卫生—心血管疾病]