不同血压分级原发性高血压患者血清CysC和CTRP9水平的表达及临床意义  

Expression and clinical significance of serum CysC and CTRP9 levels in patients with essential hypertension with different blood pressure grades

作　　者：郭靓 赵鑫[1] 强雪芹 GUO Liang;ZHAO Xin;QIANG Xue-qin(Department of Clinical laboratory,Chengdu 7th People's Hospital(Chengdu Cancer Hospital),Chengdu Sichuan 610123,China)

机构地区：[1]成都市第七人民医院(成都市肿瘤医院)检验科

出　　处：《临床和实验医学杂志》2019年第19期2078-2081,共4页Journal of Clinical and Experimental Medicine

基　　金：四川省卫生和计划生育委员会科研课题(编号:17PJ526)

摘　　要：目的观察不同血压分级原发性高血压患者血清胱抑素C(CysC)、C1q/肿瘤坏死因子相关蛋白9(CTRP9)水平的表达差异,并评价其临床意义。方法采用回顾性研究方法,选取2018年1月至2019年1月成都市第七人民医院收治的134例原发性高血压患者作为研究对象,其中,舒张压90~99 mmHg和(或)收缩压140~159 mmHg者纳入Ⅰ级组(n=49),舒张压100~109 mmHg和(或)收缩压160~179 mmHg者纳入Ⅱ级组(n=46),舒张压≥110 mmHg和(或)收缩压≥180 mmHg者纳入Ⅲ级组(n=39),比较三组患者的血清CysC、CTRP9水平及其与平均动脉压(MAP)、颈动脉内膜中层厚度(cIMT)、踝臂脉搏波传导速度(baPWV)以及超敏C反应蛋白(hs-CRP)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的关系。结果三组患者的血清CysC(0.79±0.29 mg/L vs.0.85±0.34 mg/L vs.1.11±0.37 mg/L)、CTRP9(141.22±32.56 ng/ml vs.124.37±26.49 ng/ml vs.109.52±26.54 ng/ml)、MAP(104.29±10.36 mmHg vs.115.38±12.45 mmHg vs.121.47±13.44 mmHg)、cIMT(0.98±0.31 mm vs.1.22±0.44 mm vs.1.35±0.41 mm)、baPWV(18.49±3.25 m/s vs.23.49±3.29 m/s vs.29.57±4.02 m/s)、hs-CRP(5.39±4.08 mg/L vs.8.26±4.27 mg/L vs.12.55±6.22 mg/L)、HDL-C(1.16±0.32 mmol/L vs.1.19±0.33 mmol/L vs.1.7±0.30 mmol/L)、LDL-C(2.78±0.95 mmol/L vs.2.89±0.97 mmol/L vs.2.90±0.98 mmol/L)的水平比较,差异均具有统计学意义(P<0.05)。经相关性分析显示,血清CysC与MAP、cIMT、baPWV均呈正相关性(r=0.483、0.423、0.343,P<0.05),血清CTRP9与MAP、cIMT、hs-CRP、LDL-C均呈负相关性(r=-0.339、0.293、0.375、0.330,P<0.05)。结论原发性高血压随着分级的不断提升,患者血清CysC随之升高、血清CTRP9随之降低;血清CysC、CTRP9水平与相关的动脉粥样硬化指标存在明显相关性,对其进行临床检测有助于判断原发性高血压患者并发动脉粥样硬化的风险。Objective To observe the differences in serum cystatin C(CysC),C1q/tumor necrosis factor-related protein 9(CTRP9)levels in patients with essential hypertension with different blood pressure grades,and to evaluate their clinical significance.Methods A retrospective study was conducted to select 134 patients with essential hypertension admitted to the Seventh People's Hospital of Chengdu from January 2018 to January 2019,including diastolic blood pressure of 90-99 mmHg and/or systolic blood pressure.Patients with 140~159 mmHg were included in the I-stage group(n=49),diastolic blood pressure 100-109 mmHg and/or systolic blood pressure 160-179 mmHg were included in the II group(n=46),diastolic blood pressure≥110 mmHg and(or Systolic blood pressure≥180 mmHg was included in the III group(n=39).Serum CysC,CTRP9 levels and mean arterial pressure(MAP),carotid intima-media thickness(cIMT),and brachial-ankle pulse wave conduction were compared between the three groups.Velocity(baPWV)and the relationship between high-sensitivity C-reactive protein(hs-CRP),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C).Results Serum CysC(0.79±0.29 mg/L vs.0.85±0.34 mg/L vs 1.11±0.37 mg/L),CTRP9(141.22±32.56 ng/ml vs.124.37±26.49 ng/ml vs.109.52±26.54 ng/ml),MAP(104.29±10.36 mmHg vs.115.38±12.45 mmHg vs.121.47±13.44 mmHg),cIMT(0.98±0.31 mm vs.1.22±0.44 mm vs.1.35±0.41 mm),baPWV(18.49±3.25 m/s vs.23.49±3.29 m/s vs.29.57±4.02 m/s),hs-CRP(5.39±4.08 mg/L vs.8.26±4.27 mg/L vs.12.55±6.22 mg/L),HDL-C(1.16±0.32 mmol/L vs.1.19±0.33 mmol/L vs.1.7±0.30 mmol/L),LDL-C(2.78±0.95 mmol/L vs.2.89±0.97 mmol/L vs.2.90±0.98 mmol/L).The differences were statistically significant(P<0.05).Correlation analysis showed that serum CysC was positively correlated with MAP,cIMT and baPWV(r=0.483,0.423,0.343,P<0.05),serum CTRP9 Negative correlation with MAP,cIMT,hs-CRP,LDL-C(r=-0.339,0.293,0.375,0.330,P<0.05).Conclusion With the continuous improvement of the grade of essential hypertension,serum CysC an

关 键 词：原发性高血压 血压分级 胱抑素C C1q/肿瘤坏死因子相关蛋白9 动脉粥样硬化 相关性分析 

分 类 号：R54[医药卫生—心血管疾病]