肠道菌群对睡眠调节的研究进展  

Advances in intestinal flora in sleep regulation

作　　者：彭维[1] 申治富 王亚楠 皇甫亚茹 胡幼平[1] PENG Wei;SHEN Zhifu;WANG Yanan;HUANGFU Yaru;HU Youping(Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan 610075,China)

机构地区：[1]成都中医药大学

出　　处：《重庆医学》2019年第19期3346-3350,共5页Chongqing medicine

基　　金：四川省科技厅面上项目(2018JY0249)

摘　　要：本文以脑肠轴为切入点,对近5年关于肠道菌群在睡眠调节中的实验研究进行汇总,发现肠道菌群可通过脑肠轴的多种神经递质、细胞因子、下丘脑-垂体-肾上腺轴等途径,调控大脑功能,进而对睡眠机制进行调节。本综述将探讨肠道菌群、脑肠轴和睡眠障碍之间相互作用和内在联系。Based on brain-gut axis,this article summarizes experimental studies on the regulation of intestinal microbiota in sleep over the past five years,and finds that the gut microbiota can regulate brain functions through various neurotransmitters,cytokines,hypothalamic-pituitary-adrenal axis and other pathways in the brain intestinal axis,and then regulate the sleep mechanism.This review will explore the interactions and intrinsic links among the gut microbiota,brain-gut axis and sleep disorders.

关 键 词：胃肠道微生物组 脑肠轴 脑肠菌轴 睡眠觉醒障碍 

分 类 号：Q939.93[生物学—微生物学]