三维细胞培养的研究进展  

Advances in three-dimensional cell culture

作　　者：程华[1] 刘素生(综述) 韩玮(审校)[3] CHENG Hua;LIU Susheng;HAN Wei(Institute of Biology,Hebei Academy of Sciences,Shijiazhuang,Hebei 050081,China;College of Pharmacy,Hebei University,Baoding,Hebei 071002,China;Department of Tuberculosis Clinic,Shijiazhuang Fifth Hospital,Shijiazhuang,Hebei 050000,China)

机构地区：[1]河北省科学院生物研究所,石家庄050081 [2]河北大学药学院,河北保定071002 [3]河北省石家庄市第五医院结核门诊,050000

出　　处：《重庆医学》2019年第19期3363-3366,共4页Chongqing medicine

基　　金：河北省科学院两院合作项目(20171410)

摘　　要：三维细胞培养是近几年发展起来的一种新的细胞培养技术,该技术通过模拟细胞之间及细胞外基质信号传导的微环境,使细胞培养的状态更接近于生物体内。该技术有望成为现有的二维细胞培养和动物模型之间的桥梁,在疾病机制研究、药物高通量筛选及疫苗生产等领域发挥巨大作用。现就三维细胞培养在技术研究方面及应用领域中的进展进行了综述。The technology of three-dimensional cell culture is a new cell culture technology developed in recent years.This technique can simulate the microenvironment between cells and extracellular matrix in the body,making the state of cell culture closer to the organism.The technology is expected to become a bridge between the existing two dimensional cell culture and animal models,and plays a great role in the research of disease mechanism,high throughput drug screening and vaccine production.The progress of 3D cell culture in technology and application are reviewed.

关 键 词：二维细胞培养 三维细胞培养 药物评价 临床前 组织工程 

分 类 号：R319[医药卫生—基础医学]