IL-33/ST2信号通路与炎症性肠病的关系  

Relationship Between IL-33/ST2 Signal Pathway and Inflammatory Bowel Disease

作　　者：董月美 张方 赵美华[1] 马娜[1] 冯百岁[1] DONG Yuemei;ZHANG Fang;ZHAO Meihua;MA Na;FENG Baisui(Department of Gastroenterology,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou,450014)

机构地区：[1]郑州大学第二附属医院消化内科

出　　处：《胃肠病学》2019年第8期497-500,共4页Chinese Journal of Gastroenterology

基　　金：国家自然科学基金(81070288,81270452);河南省卫生计生科技创新型人才特聘学科带头人;河南省自然科学基金(162300410268);河南省医学科技攻关计划项目(201502015)

摘　　要：白细胞介素-33(IL-33)是新发现的IL-1超家族细胞因子,通过其受体ST2介导的通路参与多种免疫相关疾病的发生、发展,包括炎症性肠病(IBD),但其作用机制尚未明确。有研究显示IL-33在肠黏膜中可能发挥促炎和保护的双重作用。本文就IL-33/ST2信号通路与IBD的关系作一综述。Interleukin-33(IL-33),a novel identified member of IL-1 superfamily,is involved in the development and progress of various immune-related diseases,including inflammatory bowel disease(IBD),via its receptor ST2-mediated pathway,but the mechanism is not fully clarified.It has been reported that IL-33 plays a dual role in promoting inflammation and inducing protective effect in intestinal mucosa.This article reviewed the relationship between IL-33/ST2 signal pathway and IBD.

关 键 词：白细胞介素33 ST2 炎症性肠病 

分 类 号：R54[医药卫生—心血管疾病]