纳洛酮治疗慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭  

Observation Naloxone in Treating Acute Exacerbation of Chronic Obstructive Pulmonary Disease with Type Ⅱ Respiratory Failure

作　　者：王雷 邱晓梅[2] WANG Lei;QIU Xiaomei(Department of Respiratory Medicine,Nanyang First People’s Hospital,Nanyang Henan 473000,China;Department of Clinical Medicine,Nanyang Medical College,Nanyang Henan 473010,China)

机构地区：[1]南阳市第一人民医院呼吸内科,河南南阳473000 [2]南阳医学高等专科学校临床医学系,河南南阳473010

出　　处：《河南医学高等专科学校学报》2019年第5期590-592,共3页Journal of Henan Medical College

摘　　要：目的分析无创呼吸机联合纳洛酮治疗慢性阻塞性肺疾病(慢阻肺)急性加重期合并Ⅱ型呼吸衰竭的效果。方法选取慢阻肺急性加重期合并Ⅱ型呼吸衰竭患者72例,按数表法分为观察组与对照组,各36例。对照组给予无创呼吸机,观察组给予无创呼吸机联合纳洛酮,比较2组治疗结果。结果观察组有效率94.4%,高于对照组的75.0%,差异有统计学意义(P<0.05);治疗后,观察组二氧化碳分压(PaCO 2)、血氧饱和度(SpO 2)及血氧分压(PaO 2)分别为(47.10±4.45)mmHg、(94.78±3.40)%、(71.42±4.50)mmHg,与对照组的(51.33±4.47)mmHg、(88.01±3.39)%、(63.22±4.17)mmHg比较,差异有统计学意义(P<0.05)。结论给予慢阻肺急性加重期合并Ⅱ型呼吸衰竭患者无创呼吸机联合纳洛酮治疗,可改善血气指标,提高治疗结果。Objective To analyze the effect of noninvasive ventilator combined with Naloxone in the treatment of acute exacerbation of chronic obstructive pulmonary disease with type II respiratory failure.Methods 72 patients with acute exacerbation of chronic obstructive pulmonary disease complicated with type II respiratory failure were selected and divided into observation group and control group with 36 cases in each group.The control group was given non-invasive ventilator,while the observation group was given non-invasive ventilator combined with naloxone.The treatment results of the two groups were compared.Results The improvement rate of the observation group was 94.4%,higher than that of the control group(75.0%).The difference was statistically significant.(P<0.05).After treatment,the partial pressure of carbon dioxide,oxygen saturation and oxygen in the observation group were(47.10±4.45)mmHg,(94.78±3.40)%,(71.42±4.50)mmHg,and in the control group they were(51.33±4.47)mmHg,(88.01±3.39)%and(63.22±4.17)mmHg,respectively.The difference was statistically significant(P<0.05).Conclusion Non-invasive Ventilator combined with naloxone can improve blood gas index and improve the treatment outcome in patients with acute exacerbation of chronic obstructive pulmonary disease complicated with typeⅡrespiratory failure.

关 键 词：慢性阻塞性肺疾病 Ⅱ型呼吸衰竭 无创呼吸机 纳洛酮 临床疗效 

分 类 号：R563.05[医药卫生—呼吸系统]