50株临床分离红色毛癣菌体外药敏分析  

In Vitro Activities of Antifungal Drugs against 50 Trichophyton Rubrum Strains Isolates

作　　者：李丽娜[1] 张守民[1] 李明[2] 高丽[1] 刘丰五[2] 雷冬春[1] 刘鸿伟[1] 李振鲁[1] 周武[1] LI Lina;ZHANG Shoumin;LI Ming;GAO Li;LIU Fengwu;LEI Dongchun;LIU Hongwei;LI Zhenlu;ZHOU Wu(Department of Dermatology,Henan Provincial People’s Hospital;School of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou Henan 450003,China)

机构地区：[1]河南省人民医院皮肤性病科 [2]郑州大学药学院,郑州450003

出　　处：《河南医学高等专科学校学报》2019年第5期672-675,共4页Journal of Henan Medical College

基　　金：河南省科技攻关研究项目(112102310249)

摘　　要：目的讨论50株临床分离红色毛癣菌对5种常用抗真菌药物的敏感性。方法参照2008年美国临床和实验室标准化委员会出版的M38-A2方案,检测临床分离的50株红色毛癣菌对伊曲康唑、特比萘芬、酮康唑、灰黄霉素、氟康唑的敏感性。结果5种药物对50株红色毛癣菌最低抑菌浓度(minimum inhibitory concentration,MIC)从低至高依次为特比萘芬、伊曲康唑、灰黄霉素、酮康唑、氟康唑,其MIC值几何均数分别为0.004 5μg/L,0.084 8 mg/L,0.641 7 mg/L,1.301 3 mg/L,25.992 0 mg/L。将五组数据录入SPSS 23.0进行秩和检验显示无统计学意义。结论红色毛癣菌对伊曲康唑与特比萘芬敏感性,差异无统计学意义(P>0.05);对氟康唑耐药,特比奈芬MIC最低。Objective To investigate the in vitro susceptibility of antifungal drugs against 50 strains of Trichophyton rubrum clinical isolated.Methods Refering to the M38-A2 Program published by the American Committee of Clinical and Laboratory Standardization,2008,the authors detected the MIC of itraconazole,terbinafine,ketoconazole,griseofulvin,fluconazole against 50 Trichophyton rubrum strains.Results The geometric mean of MIC was 0.004 5 mg/L(terbinafine),0.084 8 mg/L(itraconazole),0.641 7 mg/L(griseofulvin),1.301 3 mg/L(ketoconazole),25.992 0 mg/L(fluconazole).There were significant differences in the susceptibility among these drugs.Conclusion There is no significant statistics difference in the sensitivity of Trichophyton rubrum to itraconazole and terbinafine.Trichophyton rubrum is resistant to fluconazole.The MIC of terbinafine is the tower.

关 键 词：皮肤癣菌 红色毛癣菌 药敏试验 

分 类 号：R756[医药卫生—皮肤病学与性病学] R446[医药卫生—临床医学]