参附注射液对老年妇科肿瘤患者术后认知功能的评估  

EVALUATION OF THE COGNITIVE FUNCTION OF SHENFU INJECTION IN POSTOPERATIVE ELDERLY PATIENTS WITH GYNECOLOGICAL TUMOR

作　　者：杨娟[1] 刘勇华[1] 杨绍田[1] 程国梅[2] YANG Juan;LIU Yonghua;YANG Shaotian;CHENG Guomei(Medical School of Huaughe Science and Technology College,Zhengzhou Henan 450006;The Third Affiliated Hospital of Zhengzhou University,Zheugzhuo Henan 450006)

机构地区：[1]黄河科技学院医学院,河南郑州450006 [2]郑州大学第三附属医院,河南郑州450006

出　　处：《黄河科技学院学报》2019年第5期7-10,共4页Journal of Huanghe S&T College

基　　金：2017年河南省科技厅科技发展项目“卵巢上皮癌中HDAC2与p21相关作用的研究”(编号:172102310528)

摘　　要：选取在全麻下老年妇科肿瘤手术患者160例,年龄60~80岁,随机分为研究组和对照组,每组80例。研究组在麻醉诱导气管插管后给予参附注射液100 ml加5%葡萄糖注射液250 ml静脉滴注,对照组只给予5%的葡萄糖注射液350 ml。为检测患者认知功能,在术前1d,术后1、3、5 d,采用简易精神状态量表(MMSE)进行测定。分别采术前(TO)、术后(T1)及术后24h(T2)静脉血2ml,检测血清S100β蛋白含量。研究组术后1、3、5 d认知功能评分优于对照组,其差异有统计学意义(P<0.01)。研究组术后认知功能障碍(POCD)的发生率为(3d:15%,5d:10%)与对照组相比(3d:35%,5 d:30%)下降,差异有统计学意义(P<0.05)。对照组术后5d有2例(10%)出现重度POCD,而研究组术后5d未出现重度POCD,两组术后5d重度POCD发生率比较,差异有统计学意义(P<0.05)。研究组在T1时血清S100β蛋白含量较对照组下降((P<0.01)。应用参附注射液可以降低POCD发生率,提高妇科肿瘤全麻患者术后的认知功能。160 cases of senile patients with gynecological tumor operation under general anesthesia,aged 60 to 80 years old?were randomly divided into study group and control group,80 cases?in each.100ml of Shenfu injection plus 250ml 50g/L glucose injection by intravenous infusion was administered to study group at intubation?after induction of anesthesia,and 350ml 50g/L Glucose to control group.The mini mental state examination(MMSE)is applied 1d before and 1,3 and 5d after operation for the determination of cognitive function.The venous blood is extracted before operation(TO),at the end of operation(T1)and 24h after operation(T2)was extracted to deter-mine the content of Serum S100βprotein.The cognitive function scores of study group on the 1st,3rd and 5th day were better than that of control group,and the difference was statistically significant(P<0.01).The postoperative dysfunction(POCD)cognitive incidence(3d:15%,5d∶10%)in the study group was lower than that in the control group(3d:35%,7d∶30%),a fact showing the difference was statistically significant(P<0.05).2 cases(10%)of severe POCD were found in the control group 5d after operation but none found in the study group.The difference in severe POCD incidence?between the two groups was statistically significant(P<0.05).The serum S100βprotein content in the study group at T1 was lower than that of control group((P<0.01).The application of Shenfu injection can improve the cognitive function of patients with gynecologic tumor after operation under general anesthesia operation and reduce the incidence of POCD.

关 键 词：参附注射液 S100Β蛋白 手术后 认知功能 

分 类 号：R4[医药卫生—临床医学]