一次性使用无菌注射器中残留单体检测  

Detection of residual monomers in disposable sterile syringes

作　　者：李永贵 王大鹏 马丽霞 王晶 LI Yonggui;WANG Dapeng;MA Lixia;WANG Jing(Shandong Academy of Pharmaceutical Sciences,Shandong Provincial Key Laboratory of Chemical Drug,Jinan 250101,China;Shandong Academy of Pharmaceutical Sciences,Shandong Provincial Key Laboratory of Biomedical Polymers,Jinan 250101)

机构地区：[1]山东省药学科学院山东省化学药物重点实验室,济南250101 [2]山东省药学科学院山东省医用高分子材料重点实验室,济南250101

出　　处：《生物医学工程研究》2019年第3期367-369,共3页Journal Of Biomedical Engineering Research

基　　金：山东省重点研发计划项目(2018GSF118132)

摘　　要：本研究建立了一次性使用无菌注射器中残留单体DCPD、TCD和MTF的气相检测方法。采用100%聚硅氧烷柱(30 m×0.32 mm×0.25μm),柱温155℃,载气为氮气,氢火焰离子化器(FID),进样口温度240℃,检测器温度250℃,分流比5∶1,进样量1.0μL。结果显示三种单体DCPD、TCD、MTF分离良好,在相应范围内线性关系良好,相关系数均大于0.999,平均加样回收率均在97%~102%,RSD值均小于2%。该方法专属性强、准确度高,可用于DCPD、TCD和MTF三种残留单体的检测。We established a gas phase detection method for residual monomers DCPD,TCD and MTF in disposable sterile syringes;a 100%polysiloxane column(30 m×0.32 mm×0.25 um)was used with column temperature of 155℃.The carrier gas was nitrogen,the injection port temperature was 240℃,and the temperature of FID was 250℃,the split ratio was 5:1 and the sample volume was set at 1.0μL.The results showed that the monomers DCPD,TCD and MTF were well separated.Each monomer had a good linear relationship in the appropriate concentration range,and the correlation coefficient was greater than 0.999,the average recoveries were 97%~102%,and the RSDs were less than 2%.The method has strong specificity and high accuracy and can be used in the detection of three residual monomers of DCPD,TCD and MTF.

关 键 词：无菌注射器 残留单体 双环戊二烯 气相色谱 检测 

分 类 号：R318[医药卫生—生物医学工程]