小血管病性认知障碍与大动脉粥样硬化性认知障碍危险因素差异的研究  

Study on the Difference of Risk Factors between Small Vascular Cognitive Impairment and Large Atherosclerotic Cognitive Impairment

作　　者：安晓雷[1] 李传玲[1] 郭靖[1] 欧春影[1] 李晓宾[1] 许可[1] AN Xiaolei;LI Chuanling;GUO Jing(Xuzhou Central Hospital,Xuzhou 221009,China)

机构地区：[1]江苏省徐州市中心医院

出　　处：《中国医学创新》2019年第27期1-4,共4页Medical Innovation of China

基　　金：2013年江苏省预防医学课题资助项目（Y2013014）;2014年江苏省科技厅临床医学专项课题（BL2014028）

摘　　要：目的:探讨小血管病性认知障碍(vascular cognitive impairment due to small vessel disease,VCI-SVD)与大动脉粥样硬化性认知障碍(vascular cognitive impairment due to large artery atherosclerosis,VCI-LAA)的危险因素差异及临床意义。方法:回顾分析110例VCI-SVD患者与102例VCI-LAA患者的人口学资料及血管危险因素,分别与100例健康体检者比较,采用多因素logistic回归分析,得到VCI-SVD与VCI-LAA的独立危险因素,并比较其不同。结果:VCI-SVD组的高hs-CRP血症、高Hcy血症、糖尿病、高血压、吸烟及饮酒比例均高于健康对照组,差异均有统计学意义(P<0.05)。VCI-LAA组高血压、脑卒中史、房颤、吸烟及饮酒比例均高于健康对照组,差异均有统计学意义(P<0.05)。logistic回归分析显示,糖尿病、高hs-CRP血症、高Hcy血症、高血压、吸烟、饮酒是VCI-SVD特有的独立危险因素(P<0.05);房颤、脑卒中史、高血压、吸烟、饮酒是VCI-LAA特有的独立危险因素(P<0.05)。结论:VCI-SVD与VCI-LAA的危险因素存在差异,针对两种类型的认知障碍的危险因素进行有针对性的干预,能延缓或减少血管性认知障碍的出现。Objective:To investigate the differences of risk factors and clinical significance between the VCI-SVD and VCI-LAA.Method:The demographic data and vascular risk factors of 110 patients with VCI-SVD and 102 patients with VCI-LAA were retrospectively analyzed and compared with 100 healthy people.Independent risk factors of VCI-SVD and VCI-LAA were obtained by multivariate logistic regression analysis,and their differences were compared.Result:The proportion of high hs-CRP,high Hcy,diabetes,hypertension,smoking and drinking in the VCI-SVD group were higher than those in the healthy control group,the differences were statistically significant(P<0.05).The proportion of hypertension,stroke history,atrial fibrillation,smoking and drinking in the VCILAA group were higher than those in the healthy control group,with statistically significant differences(P<0.05).Logistic regression analysis showed that diabetes,high hs-CRP,high Hcy,hypertension,smoking and drinking were independent risk factors specific to VCI-SVD(P<0.05).Atrial fibrillation,stroke history,hypertension,smoking and alcohol consumption were independent risk factors specific to VCI-LAA(P<0.05).Conclusion:The risk factors of VCI-SVD and VCI-LAA are different,targeted interventions for the risk factors of the two types of cognitive impairment can delay or reduce the occurrence of vascular cognitive impairment.

关 键 词：小血管病性认知障碍 大动脉粥样硬化性认知障碍 危险因素 

分 类 号：R54[医药卫生—心血管疾病]