IL-25在慢性阻塞性肺疾病患者血清中的表达及与肺功能的相关性研究  

Expression of IL-25 in Serum of Patients with COPD and Its Correlation with Lung Function

作　　者：陈咏芳[1] 符青松[1] 庄虹[1] CHENYongfang;FU Qingsong;ZHUANG Hong(Shenzhen Longgang Central Hospital,Shenzhen 518116,China)

机构地区：[1]广东省深圳市龙岗中心医院

出　　处：《中国医学创新》2019年第27期25-28,共4页Medical Innovation of China

基　　金：深圳市龙岗区科技发展资金医疗卫生（扶持类）项目（2016060616315704）

摘　　要：目的:探讨IL-25在慢性阻塞性肺疾病(COPD)患者血清中的表达及与肺功能的相关性。方法:选择2016年1月-2018年12月本院收治的COPD急性加重期48例设为急性加重期组,同期选取经治疗缓解后8周无急性发作的COPD患者48例设为缓解期组,同期选取健康体检人群35例设为对照组,比较三组受试者的血清IL-25、EOS、N、M水平及肺功能指标FEV1、FEV1/FVC、FEF25%~75%、FEV1%pred水平变化情况,并采用Pearson相关性分析血清IL-25及各炎性指标与肺功能的相关性。结果:与对照组比较,缓解期组与急性加重期组IL-25、EOS、N水平均明显升高,且急性加重期组高于缓解期组,而M、FEV1、FEV1/FVC、FEF25%~75%、FEV1%pred水平均明显降低,且急性加重期组低于缓解期组,差异均有统计学意义(P<0.05);经Pearson相关性分析显示,血清IL-25、N与FEV1、FEV1/FVC、FEF25%~75%、FEV1%pred均呈负相关(P<0.05);EOS仅与FEV1/FVC呈负相关(P<0.05);M与FEV1、FEV1/FVC、FEF25%~75%、FEV1%pred均呈正相关(P<0.05)。结论:COPD患者存在IL-25水平异常,其可能参与了病情的发生、发展,且与患者肺功能关系密切,对其检测在COPD患者的诊治中具有重要价值。Objective:To investigate the expression of IL-25 in serum of patients with chronic obstructive pulmonary disease(COPD)and its correlation with lung function.Method:A total of 48 patients with acute exacerbation of COPD admitted to our hospital from January 2016 to December 2018 were enrolled in the acute exacerbation group,48 patients with COPD without acute exacerbation 8 weeks after treatment remission were set as remission group.In the same period,35 healthy people were selected as the control group.Serum IL-25,EOS,N,M levels and lung function indexes FEV1,FEV1/FVC,FEF25%-75%,and FEV1%pred were compared among three groups.Changes were made and Pearson correlation was used to analyze the correlation between serum IL-25 and various inflammatory markers and lung function.Result:Compared with the control group,IL-25,EOS,and N levels were significantly higher than those in the remission group and the acute exacerbation group,and the acute exacerbation group were higher than those of the remission group,while M,FEV1,FEV1/FVC and FEF25%-75%,FEV1%pred level were significantly lower,and the acute exacerbation group were lower than those of the remission group,the above differences were statistically significant(P<0.05).Pearson correlation analysis showed that serum IL-25,N and FEV1,FEV1/FVC,FEF25%-75% and FEV1%pred were negatively correlated(P<0.05),EOS was only negatively correlated with FEV1/FVC(P<0.05),M and FEV1,FEV1/FVC,FEF25%-75%,FEV1%pred were positively correlated(P<0.05).Conclusion:Patients with COPD have abnormal IL-25 levels,which are involved in the occurrence and development of the disease,and are closely related to the lung function of patients,it is of great value in the diagnosis and treatment of patients with COPD.

关 键 词：IL-25 COPD 肺功能 炎性指标 相关性 

分 类 号：R56[医药卫生—呼吸系统]