异位嗅觉受体在皮肤病中的研究进展  

Advances in the study of ectopic olfactory receptors in skin diseases

作　　者：闵敏 张汝芝[1] MIN Min;ZHANG Ru-zhi(Department of Dermatology,The First People’s Hospital of Changzhou,Changzhou,Jiangsu 213000)

机构地区：[1]江苏省常州市第一人民医院

出　　处：《皮肤病与性病》2019年第5期658-660,共3页Dermatology and Venereology

基　　金：2018年常州市科技计划应用基础研究项目（CJ20180024)

摘　　要：嗅觉受体主要位于鼻上皮细胞嗅觉神经元的表面。近年来研究表明,ORs异位性表达于各种人体非嗅觉组织中,如心脏、肺、精子、皮肤和癌组织等。皮肤作为人体最外层的屏障,暴露在多种环境因素下,直接与环境中的多种化学物质发生联系。研究发现,异位ORs在角质形成细胞、黑素细胞等皮肤组织细胞中存在表达,参与多种生物学功能。此外,异位嗅觉受体还与银屑病、特应性皮炎、黑素瘤等皮肤病存在关联。笔者对近年来有关异位ORs在皮肤中的表达、功能以及与皮肤相关疾病的关联研究做一综述。Olfactory receptors(ORs) are mainly located at the surface of the nasal epithelium olfactory neurons. Recent studies have shown that olfactory receptor ectopically expressed in a variety of human non-olfactory tissues, such as heart, lung, sperm, skin and cancer tissues. Skin, as the outer barrier of human body, is exposed to a variety of environmental factors and is directly connected with a variety of chemicals in the environment. Studies have shown that ectopic olfactory receptors are expressed in keratinocytes, melanocytes and other skin tissue cells, and are involved in a variety of biological functions. In addition, ectopic olfactory receptors are also associated with psoriasis, atopic dermatitis melanoma and other skin diseases. This paper reviews the recent studies on the expression and function of ectopic olfactory receptors in skin and their association with skin diseases.

关 键 词：嗅觉受体 角质形成细胞 黑素细胞 银屑病 黑素瘤 

分 类 号：R446.62[医药卫生—诊断学] R751[医药卫生—临床医学]