他汀类药物联合抗血小板药物降低冠状动脉搭桥术后血管再狭窄的研究  

Study of Statins Combined with Antiplatelet Drugs to Reduce Vascular Restenosis after Coronary Artery Bypass Grafting

作　　者：韦奇 高振轩 高阳 任京媛[2] WEI Qi;GAO Zhen-xuan;GAO Yang;REN Jing-yuan(Major in Clinical Medicine,Grade 2015,Capital Medical University,Beijing 100069,China;Department of Hypertension,Beijing Anzhen Hospital,Capital Medical University,Beijing 100025,China)

机构地区：[1]首都医科大学2015级临床医学专业,北京100069 [2]首都医科大学附属北京安贞医院高血压科,北京100025

出　　处：《医学信息》2019年第20期40-44,共5页Journal of Medical Information

基　　金：首都医科大学“本科生科研创新”项目(编号：XSKY2018193)

摘　　要：冠状动脉旁路移植术(CABG)是治疗冠心病有效手段之一,但是其术后易发生桥静脉再狭窄甚至闭塞,发生复发性心绞痛、心肌梗死以及再次血运重建的风险增加。抗血小板药物和他汀类药物是临床提高桥血管通畅率的常用药物,抗血小板药物能减少早期的血栓形成,他汀类药物能够延缓中期的内膜增厚和晚期的粥样斑块的形成。本文就联合使用抗血小板药物和他汀类药物降低CABG术后血管再狭窄的研究作一综述,并对综合治疗CABG术后血管再狭窄的方法进行展望。Coronary artery bypass grafting(CABG)is one of the effective methods for the treatment of coronary heart disease,but it is prone to restenosis or even occlusion of the bridge vein,and the risk of recurrent angina pectoris,myocardial infarction and revascularization is increased.Antiplatelet drugs and statins are commonly used drugs to improve the patency rate of bridge blood vessels.Antiplatelet drugs can reduce early thrombosis.Statins can delay the formation of metaphase intimal thickening and advanced atheroma.This article reviews the use of antiplatelet drugs and statins to reduce vascular restenosis after CABG,and prospects for the comprehensive treatment of vascular restenosis after CABG.

关 键 词：冠状动脉旁路移植术 血管再狭窄 抗血小板药物 他汀类药物 

分 类 号：R543[医药卫生—心血管疾病]