卡介菌多糖核酸对寻常型白癜风患者外周血Treg细胞的影响  

Effect of BCG-polysaccharide Nucleic Acid on Peripheral Blood Treg Cells in Patients with Vitiligo Vulgaris

作　　者：郭利平[1] 牛瑞兵[2] 东晓仙[1] 郭隽[1] GUO Li-ping;NIU Rui-bing;DONG Xiao-xian;GUO Jun(Department of Dermatology,Erdos City Center Hospital,Erdos 017000,Inner Mongolia,China;Department of Clinical Laboratory,Erdos City Center Hospital,Erdos 017000,Inner Mongolia,China)

机构地区：[1]鄂尔多斯市中心医院皮肤科,内蒙古鄂尔多斯017000 [2]鄂尔多斯市中心医院检验科,内蒙古鄂尔多斯017000

出　　处：《医学信息》2019年第20期82-84,共3页Journal of Medical Information

基　　金：鄂尔多斯市中心医院自主科研计划项目(编号：EY2014002)

摘　　要：目的探讨卡介菌多糖核酸BCG-PSN联合308 nm准分子光对寻常型白癜风患者外周血Treg细胞的影响。方法选取2013年9月~2017年5月我院收治的寻常型白癜风患者120例设为治疗组,采用随机数字表法分成Ⅰ组和Ⅱ组,各60例。Ⅰ组采用308 nm准分子光单独治疗,Ⅱ组联合卡介菌多糖核酸肌注。另选取同期我院健康体检者30例作为对照组,比较治疗组与对照组外周血Treg细胞比值、治疗组不同分期外周血Treg细胞比值、各组治疗前后外周血Treg细胞比值以及Ⅰ组和Ⅱ组治疗总有效率。结果治疗组外周血Treg细胞比值低于对照组,差异有统计学意义(P<0.05);进展期外周血Treg细胞比值低于稳定期,差异有统计学意义(P<0.05);与对照组比较,Treg细胞比值均降低,且进展期下降更明显;治疗后Ⅰ组、Ⅱ组Treg细胞比值均较治疗前升高,且Ⅱ组升高更为明显,差异有统计学意义(P<0.05);治疗后Ⅰ组Treg细胞比值低于对照组,差异有统计学意义(P<0.05);Ⅱ组治疗总有效率高于Ⅰ组,差异有统计学意义(P<0.05)。结论BCG-PSN可以通过增加Treg细胞水平提高患者细胞免疫功能,临床疗效确切,安全性高,不良反应少,值得临床应用。Objective To investigate the effect of BCG-PSN combined with 308 nm excimer light on peripheral blood Treg cells in patients with vitiligo vulgaris.Methods 120 patients with vitiligo vulgaris admitted to our hospital from September 2013 to May 2017 were enrolled in the treatment group.They were divided into group I and group II by random number table,60 cases each.Group I was treated with 308 nm excimer light alone,and group II was combined with BCG polysaccharide nucleic acid.In addition,30 healthy subjects in our hospital were selected as the control group.The ratio of peripheral blood Treg cells in the treatment group and the control group,the ratio of Treg cells in the peripheral blood of the different treatment groups,the ratio of Treg cells in the peripheral blood of each group before and after treatment,and the groups I and II.The total effective rate of treatment in the group.Results The ratio of Treg cells in the peripheral blood of the treatment group was lower than that of the control group,the difference was statistically significant(P<0.05).The ratio of Treg cells in the peripheral blood was lower than that in the stable phase,the difference was statistically significant(P<0.05).Compared with the control group,the ratio of Treg cells decreased,and the progression decreased.Obviously,the ratio of Treg cells in group I and group II increased after treatment,and the increase in group II was more significant,the difference was statistically significant(P<0.05).The ratio of Treg cells in group I after treatment was compared with the control group,the difference was statistically significant(P<0.05).The total effective rate of group II was higher than that of group I,the difference was statistically significant(P<0.05).Conclusion BCG-PSN can improve the cellular immune function of patients by increasing the level of Treg cells.The clinical efficacy is clear,the safety is high,and the adverse reactions are few,which is worthy of clinical application.

关 键 词：寻常型白癜风 卡介菌多糖核酸 TREG细胞 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]