PLA/nano-SiO2/HA三元复合生物材料的力学及体外降解性能研究  

Study on Mechanical and In-vitro Degradation Properties of PLA/nano-SiO2/HA Ternary Composite Biomaterials

作　　者：余旺旺[1,2] 李卫红[1] 张静[1] 顾海 Yu Wangwang;Li Weihong;Zhang Jing;Gu Hai(Nanjing Forestry University,Nanjing 210037,China;Nanjing Institute of Industry Technology,Nanjing 210023,China;Jiangsu Key Laboratory of 3D Printing Equipment and Application Technology,Nantong Institute of Technology,Nantong 226003,China)

机构地区：[1]南京林业大学,江苏南京210037 [2]南京工业职业技术学院,江苏南京210023 [3]江苏省3D打印装备及应用技术重点建设实验室,江苏南通226003

出　　处：《塑料科技》2019年第10期83-87,共5页Plastics Science and Technology

基　　金：江苏省3D打印装备及应用技术重点建设实验室开放基金项目(2018KFKT06)

摘　　要：采用3D打印技术制作聚乳酸/纳米二氧化硅/羟基磷灰石(PLA/nano-SiO2/HA)三元复合生物材料,研究了复合材料的力学性能及其在磷酸盐缓冲溶液中的体外降解性能。结果表明:当nano-SiO2含量为PLA/HA复合材料质量的2%时,三元复合生物材料的综合力学性能最好,其拉伸和弯曲强度分别是85.62 MPa、126.66 MPa。随着体外降解时间的延长,三元复合生物材料的拉伸及弯曲强度将下降,但即使如此,经历12周的体外降解试验后,所有强度保持率均在80%左右,且在降解试验过程中,降解液的pH值基本维持在7.35左右,说明PLA/nano-SiO2/HA三元复合生物材料在缓冲溶液中具有足够高的强度,且对环境影响较小,有望应用于一些组织工程中。PLA/nano-SiO2/HA ternary composite biomaterials were fabricated by three-dimensional printing technology.The mechanical properties of the composites and their degradation in phosphate buffer solution were studied.The results show that when the content of nano-SiO2 is 2%of the mass of PLA/HA composites,the comprehensive strength of ternary composite biomaterials is the best.The tensile and bending strength of ternary composite biomaterials are 85.62 MPa and 126.66 MPa,respectively.With the extension of degradation time in vitro,the tensile and flexural strength of ternary composite biomaterials will decrease.Nevertheless,after 12 weeks of in vitro degradation test,all the strength retention rates are about 80%,and the pH value of the degradation solution remained about 7.35 during the degradation test,which indicate that PLA/nano-SiO2/HA ternary composite biomaterials has sufficient strength in buffer solution,and that the strength of PLA/nano SiO2/HA ternary composite biomaterials is high enough.It has less impact on the environment and is expected to be applied in some tissue engineering.

关 键 词：聚乳酸/纳米二氧化硅/羟基磷灰石三元复合生物材料 力学性能 体外降解性能 

分 类 号：TQ323.4[化学工程—合成树脂塑料工业]