脂质纳米注射剂的研究与应用前景  

Research Advances and Application Prospect of Lipid Nanoinjection

作　　者：高谐 丁杨 周建平 GAO Xie;DING Yang;ZHOU Jianping(Dept,of Pharmaceutics,China Pharmaceutical University,Nanjing 210009)

机构地区：[1]中国药科大学药学院药剂系

出　　处：《中国医药工业杂志》2019年第10期1098-1112,共15页Chinese Journal of Pharmaceuticals

基　　金：国家药典委药品医疗器械审评审批制度改革项目(ZG2017-4-01、 ZG2018-7-01);国家科技重大专项(2017ZX09101001);国家自然科学基金面上项目(81872819、81573379);中国药科大学双一流建设创新团队(CPU2018GY26)

摘　　要：脂质纳米注射剂是以天然或合成脂质载体为基础,具有优良靶向性、生物相容性、多药荷载性的新型纳米递药系统。以脂质纳米注射剂递送的多数药物克服了原注射剂体内半衰期短、药物溶解性差和不良反应大等缺陷,具有良好的临床应用前景。本文综述了脂质体、注射乳、固体脂质纳米粒、药质体、脂蛋白等脂质纳米注射剂的临床与产品化应用现状,以及诊疗应用研究现状,为复杂注射剂的临床应用与研发提供参考。Lipid nanoinjections derived from natural or synthetic lipid carriers possess super targeting ability,tissue affinity and multiple drug loading capacity.Lipid nanoinjection-mediated numerous drugs have overcome many clinical defects,including short biological half-life,poor drug solubility and severe toxic effects for traditional intravenous injection,which provides better applicable prospects.In this review,the status of clinical and commercialization applications of lipid nanoinjections such as liposomes,emulsion injections,solid lipid nanoparticles,pharmacosomes and lipoproteins,are summarized.Moreover,this review provides a reference for clinical application and R&D of lipid nanoinjections.

关 键 词：脂质纳米注射剂 复杂注射剂 脂质体 注射乳 固体脂质纳米粒 药质体 脂蛋白 

分 类 号：R944.9[医药卫生—药剂学]