木芙蓉叶提取物体外抗RSV作用机制研究  

Study on the anti-RSV mechanism of extracts from Hibiscus mutabilis leaf in vitro

作　　者：崔真真 牛凤菊[2] 郭玲燕 吴芳 周长征[1] 辛义周[3] CUI Zhen-zhen;NIU Feng-ju;GUO Ling-yan;WU Fang;ZHOU Chang-zheng;XIN Yi-zhou(Shandong University of Traditional Chinese Medicine,Jinan,250355,China;Shandong Institute of Traditional Chinese Medicine,Jinan,250013,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,250011,China)

机构地区：[1]山东中医药大学,山东济南250355 [2]山东省中医药研究院,山东济南250013 [3]山东中医药大学附属医院,山东济南250011

出　　处：《海南医学院学报》2019年第20期1553-1556,1561,共5页Journal of Hainan Medical University

基　　金：山东省自然科学基金资助项目(ZR2016HL53)~~

摘　　要：目的:研究木芙蓉叶提取物的体外抗呼吸道合胞病毒(respiratory syncytial viruses,RSV)作用机制。方法:以利巴韦林为对照药物,检测木芙蓉叶提取物抗RSV的活性。通过观察木芙蓉叶提取物不同给药方式的抗病毒作用,对木芙蓉叶提取物抗RSV的作用机制进行初探。结果:木芙蓉叶提取物能有效抑制RSV引起的细胞病变,具有显著的抗病毒作用,治疗指数(therapeutic index,TI)为86.24。木芙蓉叶提取物对病毒的直接灭活作用,同时具有预防和治疗的作用。结论:木芙蓉叶提取物在体外具有显著的抗RSV作用,且其抗病毒作用发生在病毒穿入细胞后的阶段。Objective:To study the anti-respiratory syncytial viruses(RSV)mechanism of extracts from Hibiscus mutabilis leaf in vitro.Methods:Elibavirin was used as the positive drug to detect the anti-RSV activity of extracts from Hibiscus mutabilis leaf.By observing the antiviral effect of the extracts of Hibiscus mutabilis leaf in different ways of administration,the anti-RSV mechanism of the extracts of Hibiscus mutabilis leaf was preliminarily explored.Results:Hibiscus mutabilis leaf extracts could effectively inhibit the cytopathic changes caused by RSV,and had significant antiviral effect.The therapeutic index was 86.24.Conclusion:Hibiscus mutabilis leaf extracts have significant anti-RSV effect in vitro,and their antiviral effect occurs after virus penetration.

关 键 词：木芙蓉叶提取物 RSV 抗病毒作用 

分 类 号：R285.5[医药卫生—中药学]