ECP、25-羟维生素D3、M2受体在小儿支气管哮喘急性发作期中的表达及意义  

The expression and significance of ECP, 25-hydroxyvitamin D3 and M2 receptors in children with acute attack of bronchial asthma

作　　者：潘俊秀 张磊[2] 何君礼[3] 范楚平[1] PAN Jun-xiu;ZHANG Lei;HE Jun-li;FAN Chu-ping(Department of Children's Respiration,Children's Hospital of Chenzhou First People's Hospital,Chenzhou,Hunan,423000;Medical Department of Children's Hospital of Chenzhou First People's Hospital,Chenzhou,Hunan,423000;PICU,Children's Hospital of Chenzhou First People's Hospital,Chenzhou,Hunan,423000)

机构地区：[1]郴州市第一人民医院儿童医院儿童呼吸科,湖南郴州423000 [2]郴州市第一人民医院儿童医院医务科,湖南郴州423000 [3]郴州市第一人民医院儿童医院PICU,湖南郴州423000

出　　处：《海南医学院学报》2019年第20期1566-1570,共5页Journal of Hainan Medical University

基　　金：郴州市科技局资助重点项目(CZ2013065)~~

摘　　要：目的:嗜酸细胞阳离子蛋白(ECP)、25-羟维生素D 3[25-(OH)D3]、M2受体在小儿支气管哮喘急性发作期中的表达及意义。方法:选取在本院首次就诊的支气管哮喘患儿70例,分为慢性持续期组、缓解期组、急性发作期组。选取在本院进行体检的健康儿童30例,作为对照组。采用酶联免疫吸附试验,检测ECP、25-(OH)D3、M2受体水平,进行Pearson相关性分析。结果:与对照组相比,慢性持续期组、缓解期组、急性发作期组患儿ECP、M2受体水平升高,25-(OH)D3水平降低(P<0.05)。急性发作期组患儿ECP、M2受体水平高于慢性持续期组,25-(OH)D3水平低于慢性持续期组(P<0.05)。急性发作期组患儿ECP、M2受体水平高于缓解期组,25-(OH)D3水平低于缓解期组(P<0.05)。与轻度患儿相比,中度和重度患儿ECP、M2受体水平升高,25-(OH)D3水平降低(P<0.05)。与中度患儿相比,重度患儿ECP、M2受体水平升高,25-(OH)D3水平降低(P<0.05)。ECP与25-(OH)D 3之间呈负相关(r=-0.380,P=0.038);25-(OH)D 3与M2受体之间呈负相关(r=-0.448,P=0.013);ECP与M2受体之间呈正相关(r=0.450,P=0.013)。结论:ECP和M2受体在小儿支气管哮喘急性发作期中表达升高,25-羟维生素D3在小儿支气管哮喘急性发作期中表达降低,ECP、25-(OH)D 3、M2受体之间具有相关性,在小儿支气管哮喘急性发作期的临床诊断中意义重大。Objective:The expression and significance of Eosinophilic cationic protein(ECP),25-hydroxyvitamin D 3(25-(OH)D 3)and M2 receptor in children with acute attack of bronchial asthma.Methods:Totally Seventy children with bronchial asthma who first visited our hospital from September 2016 to September 2018 were divided into chronic persistence group,remission group and acute attack group.Thirty healthy children who underwent physical examination in our hospital were selected and divided into control group.The levels of ECP,25-(OH)D 3 and M2 receptors were analyzed by ELISA,and Pearson correlation analysis was performed.Results:Compared with the control group,the levels of ECP and M2 receptors in chronic persistence group,remission group and acute attack group increased,while the levels of 25-(OH)D 3 decreased,with statistical difference(P<0.05).The levels of ECP and M2 receptors in acute attack group were higher than those in chronic persistence group,and the levels of 25-(OH)D 3 were lower than those in chronic persistence group(P<0.05).The levels of ECP and M2 receptors in acute attack group were higher than those in remission group,and the levels of 25-(OH)D 3 were lower than those in remission group(P<0.05).Compared with mild children,the levels of ECP and M2 receptors increased and 25-(OH)D 3 decreased in moderate and severe children(P<0.05).Compared with moderate children,the levels of ECP and M2 receptors increased and 25-(OH)D 3 decreased in severe children(P<0.05).There was a negative correlation between ECP and 25-(OH)D 3(r=-0.380,P=0.038);a negative correlation between 25-(OH)D 3 and M2 receptor(r=-0.448,P=0.013);and a positive correlation between ECP and M2 receptor(r=0.450,P=0.013).Conclusion:The expression of ECP and M2 receptors increased during the acute attack of bronchial asthma in children,while the expression of 25-hydroxyvitamin D 3 decreased during the acute attack of bronchial asthma in children.The correlation among ECP,25-(OH)D 3 and M2 receptors is significant in the clinical diagnosis of acu

关 键 词：嗜酸细胞阳离子蛋白 25-羟维生素D 3 M2受体 支气管哮喘 急性发作期 

分 类 号：R725.6[医药卫生—儿科]