大容量全肺灌洗治疗尘肺患者疗效的Meta分析  

A Meta Analysis on the Effects of the Whole Lung Lavage In Treating Pneumoconiosis

作　　者：吴晨璐 余佳鑫[1] 谢林伸[1] WU Chenlu;YU Jiaxin;XIE Linshen(West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu City 610041,Sichuan Province,China)

机构地区：[1]四川大学华西公共卫生学院/四川大学华西第四医院

出　　处：《职业卫生与病伤》2019年第5期273-279,共7页Occupational Health and Damage

摘　　要：目的探讨大容量全肺灌洗(WLL)治疗对尘肺患者近期肺功能及临床症状的影响。方法分别检索1998-2018年在CNKI、万方数据库、维普数据库、CBM、PubMed及The Cochrane Library数据库上发表的原始研究。按纳入标准对文献进行筛选并提取信息,对症状及肺功能的主要检测指标使用RevMan 5.0进行Meta分析。结果共纳入文献29篇,共计3 688例研究对象,其中5篇为随机对照试验。多数文章定性描述显示临床症状有所好转;WLL后肺通气功能指标以测量值表达的时候FVC(95%CI:0.41~0.45)、FEV(95%CI:0.26~0.37)、MVV(95%CI:0.81~1.28)和FEV1/FVC(95%CI:0.80~4.80)均有上升,差异有统计学意义(P<0.05);WLL对肺容量指标(RV/TLC)和弥散功能指标(DLCO)的影响无统计学意义(P>0.05)。结论尘肺患者经过WLL治疗后主要的呼吸系统临床症状有所改善,近期肺功能中的肺通气指标有所好转。Objective To evaluate the effect of whole lung lavage(WLL)on pulmonary functions and the clinical symptoms in pneumoconiosis patients.Methods CNKI,Wanfang Databases,VIP Databases,CBM,Pubmed and The Cochrane Library were searched for collect original studies which were published between 1998 and 2018.Articles fulfilling the inclusion criteria were reviewed systematically,and the Meta-analysis about symptoms and main pulmonary functions indicators were analyzed by RevMan 5.0.Results Total of 29 papers involving 3688 participates were finally included for Meta-analysis,and 5 of them were randomized controlled trials.Most papers showed the clinical symptoms alleviated qualitatively.The results showed that FVC(95%CI:0.41-0.45),FEV1(95%CI:0.26-0.37),MVV(95%CI:0.81-1.28),and FEV1/FVC(95%CI:0.80-4.80)were significantly increased in the measured value of pulmonary ventilation function indicators(P<0.05)after WLL;There difference between pulmonary volume and diffusion function indicator of RV/TLC and DLCO was no statiscally siginificant(P>0.05).Conclusion The main respiratory symptoms of pneumoconiosis patients alleviated accompanied with improvement of pulmonary ventilation function after WLL.

关 键 词：尘肺 大容量肺灌洗 肺功能 META分析 

分 类 号：R135.2[医药卫生—劳动卫生]