注射用甲磺酸加贝酯联合泮托拉唑钠治疗急性胰腺炎的临床效果  被引量:2

Clinical effect of gabexate mesylate and pantoprazole sodium for injection in the treatment of acute pancreatitis

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作  者:贾娇 赵纯梅 JIA Jiao;ZHAO Chun-mei(Yulin No.2 Hospital,Yulin 719000;Third Hospital of Yulin City,Yulin 719000,China)

机构地区:[1]榆林市第二医院,陕西榆林719000 [2]榆林市第三医院,陕西榆林719000

出  处:《临床医学研究与实践》2019年第30期49-50,67,共3页Clinical Research and Practice

摘  要:目的探究注射用甲磺酸加贝酯联合泮托拉唑钠治疗急性胰腺炎的临床效果。方法选取2016年6月至2018年6月榆林市第二医院和榆林市第三医院收治的130例急性胰腺炎患者作为研究对象,采用随机数字表法将其分为对照组(65例,常规治疗+注射用泮托拉唑钠)和研究组(65例,常规治疗+注射用泮托拉唑钠+注射用甲磺酸加贝酯)。比较两组的治疗效果。结果治疗后,两组患者的各项血清炎症因子(白细胞介素-6、肿瘤坏死因子-α、超敏C反应蛋白)水平均降低,且研究组低于对照组(P<0.05);研究组患者的肠道功能恢复、腹部症状消失及住院时间均短于对照组(P<0.05);研究组患者的治疗总有效率显著高于对照组(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论注射用甲磺酸加贝酯联合泮托拉唑钠治疗急性胰腺炎的临床效果显著,可有效降低患者的炎症因子水平,缩短其肠道功能恢复、腹部症状消失及住院时间,进一步提升疗效,且用药不良反应少,安全性高,值得临床推广与应用。Objective To explore the clinical effect of gabexate mesylate and pantoprazole sodium for injection in the treatment of acute pancreatitis.Methods A total of 130 patients with acute pancreatitis admitted in Yulin No.2 Hospital and Third Hospital of Yulin City from June 2016 to June 2018 were selected as the study objects and divided into control group(65 cases,routine treatment+acute pancreatitis for injection)and research group(65 cases,routine treatment+acute pancreatitis for injection+gabexate mesylate for injection).The therapeutic effects of the two groups were compared.Results After treatment,the levels of serum inflammatory factors(interleukin-6,tumor necrosis factor-α,hypersensitive C-reactive protein)in both groups decreased,and those in the research group were lower than the control group(P<0.05);the time of intestinal function recovery,abdominal symptoms disappearance and hospitalization in the research group were shorter than those in the control group(P<0.05);the total effective rate of treatment of the research group was significantly higher than that of the control group(P<0.05);there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Gabexate mesylate and pantoprazole sodium for injection in the treatment of acute pancreatitis has a significant clinical effect,which can effectively reduce the levels of inflammatory factors,shorten the time of intestinal function recovery,abdominal symptoms disappearance and hospitalization,and further improve the curative effect,with fewer adverse drug reactions and high safety.It is worthy of clinical promotion and application.

关 键 词:急性胰腺炎 注射用甲磺酸加贝酯 注射用泮托拉唑钠 

分 类 号:R975[医药卫生—药品]

 

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