基于代谢性炎症探讨解毒化浊法改善2型糖尿病胰岛素抵抗的作用  

Effect of Detoxification and Turbidification on Insulin Resistance in Type 2 Diabetes Mellitus Based on Metabolic Inflammation

作　　者：邓春艳 赵伟 韩琪臻 杨和单 DENG Chunyan;ZHAO Wei;HAN Qizhen;YANG Hedan(Guizhou University of Traditional Chinese Medicine,Guiyang 550002)

机构地区：[1]贵州中医药大学

出　　处：《中医药信息》2019年第6期43-46,共4页Information on Traditional Chinese Medicine

基　　金：国家自然科学基金地区基金项目(No.81760813);贵州省科技合作计划(No．黔科合LH字[2016]7127号)

摘　　要：目的:基于代谢性炎症探讨解毒化浊法改善2型糖尿病胰岛素抵抗的作用。方法:通过分析代谢性炎症与2型糖尿病胰岛素抵抗、浊毒与2型糖尿病胰岛素抵抗及解毒化浊法抑制代谢性炎症、改善胰岛素抵抗的相关古今文献,对解毒化浊法通过抑制代谢性炎症反应进而改善2型糖尿病胰岛素抵抗的观点进行评析。结果:文献研究表明,代谢性炎症反应在2型糖尿病胰岛素抵抗的发生发展中起着关键作用,2型糖尿病实质是慢性炎症反应性疾病;浊毒与2型糖尿病胰岛素抵抗发生发展密切相关,解毒化浊法可改善胰岛素抵抗,对2型糖尿病的治疗是有效的;解毒化浊法可抑制代谢性炎症反应,其改善2型糖尿病胰岛素抵抗的作用与抑制代谢性炎症反应有关。结论:解毒化浊法可通过抑制代谢性炎症反应从而改善2型糖尿病胰岛素抵抗,可能是解毒化浊法改善2型糖尿病胰岛素抵抗的重要机制。Objective:To investigate the effect of detoxification and turbidification on insulin resistance in type 2 diabetes mellitus based on metabolic inflammation.Methods:By analyzing the ancient and modern literature on metabolic inflammation and insulin resistance in type 2 diabetes mellitus,turbidity toxin and insulin resistance in type 2 diabetes mellitus,and the method of detoxifying and removing turbidity to inhibit metabolic inflammation and improve insulin resistance,the viewpoint of detoxification and turbidity method to improve insulin resistance in type 2 diabetes mellitus by inhibiting metabolic inflammation.Results:Literature studies showed that metabolic inflammatory reaction played a key role in the occurrence and development of insulin resistance in type 2 diabetes mellitus.Type 2 diabetes mellitus was essentially a chronic inflammatory disease.Turbidity toxicity was closely related to the occurrence and development of insulin resistance in type 2 diabetes mellitus.Detoxification and turbidification could improve insulin resistance,which was effective in the treatment of type 2 diabetes mellitus.Conclusion:Detoxification and turbidification can improve insulin resistance in type 2 diabetes mellitus by inhibiting metabolic inflammatory reaction,which may be an important mechanism for improving insulin resistance in type 2 diabetes mellitus.

关 键 词：2型糖尿病 胰岛素抵抗 代谢性炎症 解毒化浊 浊毒 

分 类 号：R259[医药卫生—中西医结合]