髓过氧化物酶（MPO）与同型半胱氨酸（Hcy）水平在急性冠状动脉综合征中的变化分析  

Changes of Myeloperoxidase(MPO) and Homocysteine(Hcy) Levels in Acute Coronary Syndrome

作　　者：王静[1] 张屯 WANG Jing;ZHANG Tun(Department of Clinical Laboratory,Sihong County People's Hospital,Sihong,Jiangsu Province,223900 China;Department of Respiratory Medicine,Fenjinting Hospital,Sihong,Jiangsu Province,223900 China)

机构地区：[1]江苏省泗洪县人民医院检验科,江苏泗洪223900 [2]江苏省泗洪县分金亭医院呼吸内科,江苏泗洪223900

出　　处：《中外医疗》2019年第27期193-195,共3页China & Foreign Medical Treatment

摘　　要：目的分析急性冠状动脉综合征中Hcy(同型半胱氨酸)和MPO(髓过氧化物酶)的变化情况。方法方便选取该院2018年1—12月收治的134例急性冠状动脉综合患者,所有患者均经冠状动脉造影确诊,以其病情为依据,将其分为不稳定性心绞痛组(n=67)与急性心肌梗死组(n=67),对两组患者行Hcy与MPO检测,同时行6个月随访,分析两组患者心源性死亡、因急性冠状动脉综合征或者心力衰竭再入院情况。结果急性心肌梗死组患者的Hcy为(19.38±6.15)μmol/L,高于不稳定性心绞痛组的(16.12±5.11)μmol/L,MPO为(3 680.25±1 102.36)pmol/L,高于不稳定性心绞痛组的(2 215.63±1 000.85)pmol/L,Gensini积分为(48.12±12.56)分,低于不稳定性心绞痛组的(59.86±15.69)分;134例急性冠状动脉综合征患者经6个月电话随访后发现,共有50例患者发生不良事件,其中6例为心源性死亡,44例因急性冠状动脉综合征或者心力衰竭再次入院;回归分析结果显示,MPO、Hcy水平和急性冠状动脉综合征患者近期预后之间存在正相关性(OR=1.001、1.126,P<0.05)。结论血浆MPO与血清Hcy和急性冠状动脉综合征患者近期发生不良心脏事件之间存在明显正相关性。Objective To analyze the changes of Hcy(homocysteine)and MPO(myeloperoxidase)in acute coronary syndrome.Methods A total of 134 patients with acute coronary artery disease admitted to the hospital from January to December 2018 were conveniently selected.All patients were diagnosed by coronary angiography.According to their condition,they were divided into unstable angina group(n=67)In the acute myocardial infarction group(n=67),Hcy and MPO were performed in both groups,and 6 months follow-up was performed to analyze cardiogenic death,re-admission of patients with acute coronary syndrome or heart failure.Results The Hcy of the patients with acute myocardial infarction was(19.38±6.15)μmol/L,which was higher than that of the unstable angina group(16.12±5.11)μmol/L,and MPO was(3 680.25±1 102.36)pmol/L,which was higher than the instability in the angina pectoris group(2 215.63±1 000.85)pmol/L,the Gensini score was(48.12±12.56)points,which was lower than that of the unstable angina group(59.86±15.69)points.After 134 patients with acute coronary syndrome who were followedup for 6 months,a total of 50 patients had adverse events,including 6 cases with cardiac death and 44 cases with acute coronary syndrome or heart failure.Regression analysis showed a positive correlation between MPO,Hcy levels and short-term prognosis in patients with acute coronary syndrome(OR=1.001,1.126,P<0.05).Conclusion There is a significant positive correlation between plasma MPO and recent adverse cardiac events in patients with serum Hcy and acute coronary syndrome.

关 键 词：急性冠状动脉综合征 同型半胱氨酸 髓过氧化物酶 变化情况 预后 

分 类 号：R541[医药卫生—心血管疾病]