血清NSE、S100B和IL-6在早产儿脑损伤的临床应用  

Clinical application value of the serum levels of NSE,S100B and IL-6 in premature infants with brain injury

作　　者：杨军 台晓燕[2] YANG Jun;TAI Xiao-yan(Department of Pediatrics,The Second Affiliated Hospital of Bengbu MedicalCollege,Bengbu Anhui 233040;Department of Pediatrics,The First Affiliated Hospital of Bengbu MedicalCollege,Bengbu Anhui 233004,China)

机构地区：[1]蚌埠医学院第二附属医院儿科,安徽蚌埠233040 [2]蚌埠医学院第一附属医院儿科,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2019年第10期1362-1364,1369,共4页Journal of Bengbu Medical College

摘　　要：目的:探讨早产儿脑白质损伤(WMD)发病率及临床表现;研究早产儿WMD早期神经元特异性烯醇化酶(NSE)、S100B蛋白(S100B)及白细胞介素-6(IL-6)值的关系。方法:选取早产儿60例,据颅脑超声和头颅MRI检查分为WMD组(18例)及无WMD作为对照组(42例),分别于出生后24 h内、7 d后采2组静脉血,应用化学发光法检测S100B、NSE和IL-6。结果:早产儿中WMD发生率为29.03%。WMD组惊厥、呼吸暂停、反应差所占比例均高于无对照组(P<0.05)。WMD组早产儿出生后24 h内、7 d后NSE、S100B、IL-6水平均高于对照组(P<0.05~P<0.01);组内比较,2组早产儿出生后7 d NSE、S100B、IL-6水平均下降,低于出生24 h内(P<0.05~P<0.01)。结论:血清NSE、S100B和IL-6水平与WMD严重程度存在相关性,WMD早产儿S100B、NSE及IL-6在生后24 h内值均显著升高,S100B与IL-6升高持续时间长,则病情越严重,则死亡风险也就越高,对WMD的早期诊断有重要指导意义。Objective:To investigate the incidence rate and clinical manifestations of premature infants with white matter damage(WMD),and explore its correlation with the serum levels of neuron-specific enolase(NSE),S100B and interleukin 6(IL-6).Methods:Sixty preterm infants were divided into the WMD group(18 cases)and control group(42 cases,non-WMD)according to the results of cranial ultrasound and head MRI examination.The serum levels of S100B,NSE and IL-6 were detected using chemiluminescence after 24 h and 7 d of birth.Results:The incidence rate of WMD in preterm infants was 29.03%.The proportion of convulsion,apnea and poor response in WMD group were higher than those in control group(P<0.05).The levels of S100B,NSE and IL-6 in WMD group were higher than those in control group after 24 h and 7 d of birth(P<0.05 to P<0.01).The levels of S100B,NSE and IL-6 in two groups after 7 d of birth decreased,which was lower than those after 24 h of birth(P<0.05 to P<0.01).Conclusions:The serum levels of NSE,S100B and IL-6 are related to the severity of WMD.The levels of S100B,NSE and IL-6 in preterm infants with WMD significantly increase after 24 h of birth.The longer the levels of S100B and IL-6 elevating duration is,the more serious the disease is,and the higher the risk of death is,which has important guiding significance in the early diagnosis of WMD in preterm infants.

关 键 词：脑白质损伤 S100B蛋白 神经元特异性烯醇化酶 白细胞介素-6 早产儿 

分 类 号：R722.6[医药卫生—儿科]