小叶型乳腺癌的PET-CT成像与Ki-67表达的相关性研究  

The research on the correlation between PET-CT imaging and Ki-67 expression in lobular breast cancer

作　　者：石俊[1] 李燕 潘森鑫[3] 刘慧慧[1] 刘文新[1] Shi Jun;Li Yan;Pan Shengxin;Liu Huihui;Liu Wenxin(Department of Radiology,Affiliated Hospital of Jiangsu University,Zhenjiang,Jiangsu 212001,China;Zhenjiang Fourth People's Hospital,Zhenjiang,Jiangsu 212001,China;PLA 359 Hospital,Zhenjiang,Jiangsu 212001,China)

机构地区：[1]江苏大学附属医院放射科,江苏镇江212001 [2]镇江市第四人民医院,江苏镇江212001 [3]解放军第359医院,江苏镇江212001

出　　处：《影像研究与医学应用》2019年第19期32-34,共3页Journal of Imaging Research and Medical Applications

摘　　要：目的:探索小叶型乳腺癌PET-CT成像与Ki-67表达的关系。方法:以2016年6月—2018年12月期间36例乳腺浸润性导管癌患者为研究对象。所有患者均行PET-CT成像。以免疫组织化学法计算肿瘤组织中Ki-67表达,依据其表达分为(-)、(+)、(++)、(+++)四组。结果:各组随着Ki-67表达递增,其镜下表现为组织细胞核内的黄色及褐色表达增多。PET-CT成像显示除CT值外,其余指标(最大截面积,体积,SUVmax,SUVmean)均存在显著差异。随后的结果发现Ki-67仅与SUVmax SUVmean存在显著正性相关。结论:PET-CT的FDG摄取最大值和平均值可作为评测肿瘤指标的可靠指标。Objective To explore the relationship between PET-CT imaging and Ki-67 expression in lobular breast cancer.Methods 36 patients with lobular breast cancer were enrolled in the study from June 2016 to December 2018 and all patients underwent PET-CT imaging.According to the expression of Ki-67,the breast cancer was divided into four subtypes:(-),(+),(++)and(+++).Results With the increasing expression of Ki-67 in each group,the microscopic expression of yellow and brown in the nucleus of the tissue was increased.PET-CT imaging showed significant differences between the indicators(maximum cross-sectional area,volume,SUVmax,SUVmean).Subsequent correlation results showed that Ki-67 was only significantly positively correlated with SUVmax SUVmean.Conclusion The maximum and average FDG uptake of PET-CT can be used as a reliable indicator for evaluating tumor markers.

关 键 词：小叶型乳腺癌 PET-CT成像 KI-67 

分 类 号：R445[医药卫生—影像医学与核医学]