甲状腺功能与冠状动脉慢性闭塞病变患者侧枝循环的关系  

Association of thyroid function with coronary circulation collaterals in patients with chronic total occlusion

作　　者：南京 李红 胡宏宇[1] 孟帅 叶慧明[2] 阮阳 曹晓菁 贾若飞 陈威[1] 陈策[2] 雷力成[2] 任利辉[2] 金泽宁 彭建军[2,3] NAN Jing;LI Hong;HU Hongyu;MENG Shuai;YE Huiming;RUAN Yang;CAO Xiaojing;JIA Ruofei;CHEN Wei;CHEN Ce;LEI Licheng;REN Lihui;JIN Zening;PENG Jianjun(Cardiovascular Department,Beijing Tian tan Hospital,Capital Medical University,Beijing 100070,China)

机构地区：[1]首都医科大学附属北京天坛医院,北京100070 [2]首都医科大学附属北京世纪坛医院,北京100038 [3]北京大学第九临床医学院,北京100038

出　　处：《实用医学杂志》2019年第19期3071-3074,共4页The Journal of Practical Medicine

基　　金：中国心血管健康联盟V.G.基金项目

摘　　要：目的对甲状腺功能与冠状动脉慢性完全闭塞性病变(chronic total occlusion,CTO)患者侧枝循环(collateral circulation,CC)之间的关系进行研究。方法对2010年1月1日至2014年12月31日期间于首都医科大学附属北京世纪坛医院心血管内科接受冠状动脉造影明确诊断为CTO的患者进行研究,根据CTO血管是否存在CC供应分为2组,对两组患者甲状腺功能与CC形成之间的关系进行分析。结果共纳入患者100例,CTO血管118条,平均(64.71±12.49)岁,有CC组患者71例,无CC组患者29例。单因素分析结果提示两组患者在性别比例、合并疾病、合并用药等方面均无显著性差异,有CC组患者吸烟比例较高,有CC组患者血肌酐水平高、血尿酸水平低、TSH水平低,FT3水平高,T3水平高。两组患者在血常规、肝功能等检查均无显著性差异。Logistic回归分析结果提示TSH水平低是CC形成的独立危险因素。结论TSH水平低、FT3以及TT3水平高与CTO患者冠状动脉CC的形成有关,TSH水平低是CC形成的独立危险因素。Objective To evaluate the association of thyroid function with coronary circulation collaterals(CC)in patients with chronic total occlusion(CTO).Method CTO patients who underwent coronary angiography in Beijing Shijitan Hospital were enrolled.The formation of CC were evaluated and relative medical history and thyroid function parameters and other clinical information were collected and analyzed.Results One hundred patients,meanly aged(64.71±12.49),and one hundred and one CTO vessels were included in the study and 71 patients with CTO were enrolled into CC formation group.Univariable analysis revealed patients with CC forma tion were more likely to smoke and have high level of creatine,FT3 and TT3,lower level of TSH and uric acid.Further logistic analysis revealed that TSH was the independent risk factor for CC formation.Conclusion Thyroid function is associated with the formation of CC in CTO patients and lower level of TSH is the independent risk fac tor of CC formation in these patients.

关 键 词：甲状腺功能 慢性完全闭塞病变 侧支循环 危险因素 

分 类 号：R54[医药卫生—心血管疾病]