HBV垂直传播形式及阻断策略  

Vertical transmission of hepatitis B virus: Modes and blocking strategies

作　　者：赵斐 刘菲[1] 王中峰[2] 李海军[3] 徐红梅[1] ZHAO Fei;LIU Fei;WANG Zhongfeng(Department of Obstetrics,The First Hospital of Jilin University,Changchun 130061,China)

机构地区：[1]吉林大学第一医院产科,长春130061 [2]吉林大学第一医院肝胆胰内科,长春130061 [3]吉林大学第一医院转化医学研究院,长春130061

出　　处：《临床肝胆病杂志》2019年第11期2557-2560,共4页Journal of Clinical Hepatology

基　　金：吉林省科技厅自然科学基金(20180101135JC)

摘　　要：在我国,母婴垂直传播是慢性乙型肝炎最主要的传播方式。受孕母体如果处于高病毒载量期,母婴垂直传播阻断失败的几率为10%左右,因此孕期正确管理HBV显得尤为重要。此外,妊娠期对病毒的处理不仅要考虑垂直传播的风险,而且要考虑孕妇的健康和胎儿的安全,每一种治疗或预防选择都需要认真评估。制订合理的抗病毒方法、药物选择、停药时间等能够合理降低母婴传播几率。总结了目前慢性乙型肝炎母婴垂直传播形式及阻断措施,为提高HBV的垂直传播阻断率提供参考。Mother-to-child vertical transmission is the main mode of transmission of chronic hepatitis B in China.The probability of failure in blocking vertical transmission is about 10% in pregnant mothers with a high viral load,and therefore,correct management of hepatitis B virus(HBV)is of great importance during pregnancy.In addition,viral treatment during pregnancy should take into account the risk of vertical transmission,the health of pregnant women,and the safety of fetus,and each treatment method or prevention option needs to be carefully evaluated.Reasonable antiviral methods,drug selection,and drug withdrawal time can reduce the probability of mother-to-child transmission.This article summarizes the modes of mother-to-child vertical transmission of chronic hepatitis B and related blocking strategies,so as to provide a reference for improving the blocking rate of vertical transmission of HBV.

关 键 词：乙型肝炎病毒 传染性疾病传播 垂直 抗病毒药 

分 类 号：R512.62[医药卫生—内科学]