不同糖代谢分类人群血清葡萄糖、三酰甘油、胆固醇及血钒水平及其相关性研究  

Serum glucose,triglyceride,cholesterol and blood vanadium levels and their correlation in different glucose metabolism populations

作　　者：董海胜[1] 钟悦 韩艳 沈起兵 向蜀霞 DONG Haisheng;ZHONG Yue;HAN Yan;SHEN Qibing;XIANG Shuxia(Key Laboratory of Space Nutrition and Food Engineering,China Astronaut Research and Training Center,Beijing 100094,China;Space Outpatient Department,Eighth Medical Center of PLA General Hospital,Beijing 100094,China;Department of Clinical Laboratory,Wangjing Hospital,China Academy of Chinese Medical Sciences,Beijing 100102,China;Shenzhen Municipal Luhang Interstellar Space Science and Technology Institute,Shenzhen,Guangdong 518116,China)

机构地区：[1]中国航天员科研训练中心航天营养与食品工程重点实验室,北京100094 [2]解放军总医院第八医学中心航天城门诊部,北京100094 [3]中国中医科学院望京医院检验科,北京100102 [4]深圳市绿航星际太空科技研究院,广东深圳518116

出　　处：《检验医学与临床》2019年第21期3111-3114,共4页Laboratory Medicine and Clinic

基　　金：载人航天预先研究项目（SNFE1602）

摘　　要：目的分析不同糖代谢分类人群血糖、三酰甘油、血胆固醇及血钒水平及其相关性。方法收集140例血清标本,根据血糖结果区分为糖代谢异常人群(DM组和IGR组)和糖代谢正常人群(NGR组),分别采用己糖激酶法(HK)、磷酸甘油氧化酶法、氧化酶-过氧化物酶-鲁米诺化学发光法及电感耦合等离子体质谱法检测其血糖、血三酰甘油、血总胆固醇及血钒水平。结果糖代谢异常人群和糖代谢正常人群各70例,DM组和IGR组血脂水平显著高于NGR组(P<0.01),DM组和IGR组血钒水平显著低于NGR组(P<0.01);而DM组和IGR组血总胆固醇水平与NGR组差异无统计学意义(P>0.05);血糖水平与血脂呈正显著相关(P<0.05),r为0.46;与血钒呈显著负相关(P<0.05),r为0.61;血糖水平与血总胆固醇不存在明显的相关性。结论对于血糖异常的人群,关注其血脂和血钒水平指标,有助于临床综合诊断并及时给予对症治疗。Objective To analyze the levels of serum glucose,triglyceride,cholesterol and blood vanadium in different glucose metabolism populations and their correlation.Methods One hundred and forty serum samples were collected and divided into the abnormal glucose metabolism population(DM group and IGR group)and normal glucose metabolism population(NGR group)according to the blood glucose results.The levels of serum glucose,triglyceride,total cholesterol and vanadium were determined by adopting the hexokinase method,phosphoglycerate oxidase method,oxidase-peroxidase-luminol method and inductively coupled plasma mass spectrometry method respectively.Results There were 70 cases of abnormal glucose metabolism and 70 cases of normal glucose metabolism.The serum lipids level in the DM group and IGR group was significantly higher than that in the NGR group(P<0.01).The serum vanadium level in the DM group and IGR group was significantly lower than that in the NGR group(P<0.01).There was no statistically significant difference in the total cholesterol level between the DM group and IGR group with the NGR group(P>0.05).The serum glucose level was positively correlated with serum lipids level,and the correlation coefficient was 0.46,which was negatively correlated with serum vanadium level,and the correlation coefficient was 0.61.There was no significant correlation between serum glucose level and total cholesterol level.Conclusion For the population with abnormal serum glucose,paying attention to its serum lipid and serum vanadium level indicators is helpful for clinical comprehensive diagnosis and timely symptomatic treatment.

关 键 词：血糖 三酰甘油 总胆固醇 钒 聚类分析 相关性 

分 类 号：R466.11[医药卫生—临床医学]